摘要
目的制备丹皮酚明胶微球并进行药剂学性质考察。方法以丹皮酚为芯材,明胶为载体,采用交联固化法制备丹皮酚明胶微球;采用正交试验优选制备工艺,并对制得的明胶微球进行体外释药性能考察。结果影响明胶微球包封率的主要因素为明胶浓度和搅拌速度。制得的明胶微球平均粒径100μm,载药量和包封率分别为8.49%和86.4%,体外释药试验表明所得微球具有明显的缓释作用。结论所选工艺可用于制备丹皮酚明胶微球,可为缓释药物传递系统提供参考。
Objective To evaluate the pharmaceutical properties of paeonolum loaded gelatin microspheres.Methods Paeonol loaded gelatin microspheres were prepared by crosslinking solidification method using paeonol as core material and gelatin as wall material.The preparation technology was optimized by orthogonal test and in vitro drug release properties of the microspheres were investigated.Results The main factors that influence the encapsulation efficiency of gelatin microspheres were gelatin concentration and stirring speed.The microspheres had an average size of 100 μm, and drug loading and encapsulation efficiency of microspheres were 8.49% and 86.4%, respectively.Conclusion The optimized process can be used to prepare paeonol loaded gelatin microspheres, which can provide reference for the development of sustained release drug delivery system.
作者
徐爱霞
杨传红
王海龙
XU Aixia YANG Chuanhong WANG Hailong(Yinan Maternal and Child Health-Care Hospital of Shandong Province, Yinan 276300, China School of Biological Science and Technology, University of Jinan, Jinan 250022, China)
出处
《药学研究》
CAS
2017年第10期589-591,601,共4页
Journal of Pharmaceutical Research
关键词
丹皮酚
微球
交联剂固化法
制备
体外释药
Paeonolum
Microspheres
Crosslinking solidification
Preparation
In vitro drug release
