摘要
目的探讨急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)患者血清生物标志物白介素-6(IL-6)、高敏C-反应蛋白(hs-CRP)、降钙素原(PCT)和D二聚体(D-D)水平的临床意义。方法采用化学发光免疫分析和电化学发光免疫分析等进行测定115例ARDS患者和80例正常对照组血清IL-6、hs-CRP、PCT和D-D水平,并进行对比性分析。受试者工作特征曲线(ROC曲线)评价转化成ARDS时血清IL-6、hs-CRP、PCT和D-D水平的临床意义。结果 115例ARDS患者血清IL-6、hs-CRP、PCT和D-D均高于正常对照组,差异有统计学意义(P<0.01)。ROC曲线表明,血清IL-6、hs-CRP、PCT和D-D的最佳临界值分别为4.35 pg/ml、7.51 mg/L、0.59 ng/ml和0.55 mg/L。曲线下面积(area under currve,AUC)、敏感度、阳性预测值和阴性预测值均依次为IL-6、hs-CRP、PCT和D-D。结论血清IL-6、hs-CRP、PCT和D-D水平具有ARDS患者早期诊断的临床价值,是评价ARDS转化的有价值指标。
Objective To explore the clinical significance of serum biomarkers in patients with acute respiratory distress syndrome（ ARDS）,such as interleukin-6（ IL-6）,high sensitive C reactive protein（ hs-CRP）,procalcitonin（ PCT） and D dipolymer（ D-D）. Methods The serum levels of IL-6,hs-CRP,PCT and D-D were determined in 115 patients with ARDS and 80 controls by chemiluminescence immunoassay and electro chimiluminesscence immunoassay for comparative analysis. Receiver operating curve（ ROC） was plotted to analyze the clinical significance of the levels of IL-6,hs-CRP,PCT and D-D as transferring ARDS. Results The serum levels of IL-6,hs-CRP,PCT and D-D in 115 patients were significantly higher than those of the control group,with the differences statistically significant（ P〈0. 01）. The ROC analysis showed that the cut-off values of IL-6,hs-CRP,PCT and D-D were 4. 35 pg/ml,7. 51 mg/L,0. 59 ng/ml and 0. 55 mg/L,respectively. The area under currve（ AUC）,the sensitivity,the positive predictive value and the negative predictive value were in the order of IL-6,hs-CRP,PCT and D-D. Conclusion The serum levels of IL-6,hs-CRP,PCT and D-D have clinical value in the early diagnosis of ARDS and are the valuable index of ARDS transfection.
出处
《中国卫生检验杂志》
CAS
2017年第19期2792-2793,2796,共3页
Chinese Journal of Health Laboratory Technology
关键词
急性呼吸窘迫综合征
生物标志物
受试者工作特征曲线
早期诊断
Acute respiratory distress syndrome
Biomarkers
Receiver operating curve characteristics
Early diagnosis
