摘要
细胞因子可分为促炎性细胞因子和抗炎性细胞因子2种类型。其中,促炎因子是一类由机体的免疫和非免疫细胞合成和分泌的小分子多肽类物质,它们调节多种细胞生理功能,并在创伤、疼痛、感染等应激过程中起重要作用。促炎性细胞因子包括白细胞介素-1(IL-1)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)、肿瘤坏死因子(TNF)等。越来越多证据表明,神经损伤后,促炎因子TNF-α,IL-1β,IL-6在脊髓和背根神经节中被诱导,并且可以导致神经痛敏反应。近年来,随着神经病理性疼痛机制研究的日趋深入和神经炎症研究领域的不断扩展,细胞因子及调控细胞因子的分子在神经病理性疼痛作用机制的阐明,有望为镇痛药物的开发提供新的作用靶点。该文就近年来研究较多的促炎因子TNF-α,IL-1β,IL-6在神经病理性疼痛的研究进行综述。
Cytokines can be divided into two types： proinflammatory cytokines and anti-inflammatory cytokines. Proinflammatory cytokines are a kind of small molecular peptides synthesized and excreted by immune and non-immune cells,which can regulate a variety of physiological functions and play an important role in the process of trauma,pain and infection. Proinflammatory cytokines include TNF,IL-1,IL-6 and IL-8. More and more evidences suggest that proinflammatory cytokines（ PICs）,such as interleukin-1β（ IL-1β）,interleukin-6（ IL-6） and tumor necrosis factor-α（ TNF-α）,are induced in the spinal cord（ SC） and dorsal root ganglion（ DRG） under various injury conditions,and contribute to pain hypersensitivity. In recent years,with the deepening of studies on neuropathic pain mechanism and the increasing expansion of the neuroinflammation study field,the action mechanisms of cytokines and molecules in regulating cytokines in neuropathic pain are expected to provide new targets for the development of analgesic drugs. This review aims to provide an overview of inflammatory mechanisms for proinflammatory cytokines TNF-α,IL-1β,IL-6,with a focus on neuropathic pain.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2017年第19期3709-3712,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金面上项目(81473414)
国家自然科学基金青年基金项目(81703845)
国家科技支撑计划课题(2011BAI07B00)
