摘要
糖尿病肾脏疾病(DKD)是糖尿病的重要并发症,AGEs及其通路在DKD的致病机制中起到重要作用。研究发现,体外皮肤AGEs荧光检测能更为准确地反映体内AGEs的蓄积程度与损伤情况,且因其无创、快捷、价格低廉与相对稳定的优势,将在预测与评估DKD发生发展中逐渐得到更广泛的临床应用。本文就近年来皮肤AGEs荧光检测DKD中的国内外应用进展作一综述。
Diabetic kidney disease（DKD） is one of the major complications of diabetes mellitus. The formation of advanced glycationend products （Advanced Glycation End-products, AGEs） has been widely accepted to play a crucial role in the pathogenesis of diabetic nephropathy. It has been reported that the skin autofluorescence test of AGEs can better reflect the AGEs accumulation in vivo, thus providing stronger evidence in predicting diabetic nephropathy. As a noninvasive, convenient and steady measure, skin autofluorescence will be widely applied in the assessment and monitoring the progress of diabetic nephropathy in the future. Here, we reviewed the research progress in skin AGEs and diabetic nephropathy.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2017年第10期938-941,共4页
Chinese Journal of Diabetes
基金
十三五国家重点研发计划项目(2016YFC 1305400
2016YFC1305401
2016YFC1305405)
北京市科技计划(D17110000281700
D17110000281701)
关键词
糖基化终产物
糖尿病肾脏疾病
皮肤荧光检测
Advanced glycation end products
Diabetic kidney disease
Skin autofluorescence
