摘要
目的探讨肝脏肿瘤射频消融术围术期血清趋化因子配体10(CXCL10)和趋化因子配体12(CXCL12)水平的变化及其临床意义。方法选取2012年12月至2015年12月期间我院确诊治疗的肝脏肿瘤射频消融术患者100例,依据术后1年是否发生复发分为复发组(n=30例)和无复组(n=70例),采用酶联免疫吸附法检测血清CXCL10和CXCL12水平,统计分析所有患者复发和围术期血清CXCL10、CXCL12水平。结果复发组术前术后血清CXCL10、CXCL12水平明显高于无复组,且复发组和无复组患者术后血清CXCL10、CXCL12水平明显低于术前,差异有统计学意义(P<0.05);Logistic回归性分析法结果显示,术前高血清CXCL10、CXCL12水平是患者术后复发的独立影响因素(P<0.05)。结论射频消融术围术期血清CXCL10和CXCL12水平与肝脏肿瘤患者复发密切相关,且高血清CXCL10和CXCL12水平是复发的独立影响因素,提示其水平变化对评估患者复发具有重要的参考价值。
Objective To investigate the change and its clinical significance of perioperative serum chemokine ligand 10（CXCL10） and chemokine ligand 12（CXCL12） level in patients with liver tumor undergoing radiofrequency ablation. Methods One hundred liver cancer patients with radiofrequency ablation were selected from December 2012 to December 2015 in our Hospital.According to the recurrence 1 year after the operation,all patients were divided into recurrence group and non-recurrence group.The level of serum CXCL10 and CXCL12 was detected by Enzyme-linked immunosorbent method,and analyzed by statistical method. Results The preoperative and postoperative serum CXCL10 and CXCL12 level of recurrence group patients were significantly lower than those of non-recurrence group,and the postoperative serum CXCL10 and CXCL12 level of recurrence group and non-recurrence group patients were significantly lower than those of the preoperative（P〈0.05）. Logistic regression analysis showed that the preoperative high serum CXCL10 and CXCL12 were independent factors for postoperative recurrence（P〈0.05）. Conclusions Radiofrequency ablation perioperative serum CXCL10 and CXCL12 levels are closely associated with recurrence of liver cancer patients,and the high level of serum CXCL10 and CXCL12 were independent factors of recurrence. Prompt assess to the change of above indexes＇ level have an important reference value for patients with recurrence.
出处
《实验与检验医学》
CAS
2017年第5期684-686,共3页
Experimental and Laboratory Medicine
