摘要
假蜜环菌甲素是从夜间发光的柳树朽木上生长的蜜环菌培养液中分离的荧光物质,化学结构为3-乙酰基-5-羟甲基-7-羟基-香豆素(Ⅵ)。该药兼有利胆、解痉、止痛、消炎等多种作用,可单独用于治疗非严重梗阻型急性胆道感染,其特点为起效快、活性高。
Much improvement was made in the synthesis of Armillarisin A. Our first efforts were focussed on developing an alternative and efficient method for the preparation of the key intermediate, 5-hydroxymethyl-resorcinal by lithium aluminium hydride reduction of methyl 3,5-diacetoxybenzoate, the yieldof this step being 84%. The final cyclization of 5-hydroxymethyl-resorcinal with one molar equivalent of methyl ethoxymethylene acetylacetate in the presence of sodium t-butoxide produced the Armillarisin A was in 76% yield.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1991年第4期236-237,共2页
Journal of China Pharmaceutical University
关键词
假蜜环菌甲素
香豆素类
合成
Armillarisin A
3-Acetyl-5-hydroxymethyl-7-hydroxy-coumarin
Choleretic drug
