摘要
目的:探讨髂内动脉栓塞联合灌注化疗(TACE)治疗进展期宫颈癌的临床疗效及对血清血管内皮生长因子(VEGF)水平的影响。方法:将72例进展期宫颈癌患者随机分两组,分别行TACE治疗(TACE组)和髂内动脉灌注化疗(IAIC组),每组36例。观察比较两组临床疗效及预后情况。同期选取36例健康志愿者为正常对照组(HC组)。比较3组血清VEGF及其受体水平。结果:宫颈癌患者血清VEGF-A、VEGF-C、VEGF-D和VEGFR-2、VEGFR-3水平均显著高于HC组(均P<0.05),治疗后TACE组和IAIC组血清VEGF及其受体水平均显著降低,且TACE组显著低于对照组(P<0.05)。TACE组治疗总有效率为88.89%,显著高于IAIC组的69.44%(P<0.05);TACE组的复发率、远处转移率显著低于IAIC组(P<0.05);TACE组1年、3年、5年生存率分别为97.22%、83.33%、75.00%,显著高于IAIC组的80.56%、61.11%、50.00%(P<0.05)。结论:TACE治疗进展期宫颈癌的疗效显著,能有效抑制VEGF及其受体表达,改善患者预后。
Objective： To investigate the clinical efficacy of trans-iliac-artery chemo-embolism （TACE）for ad- vanced cervical cancer and its effects on serum vascular endothelial growth factor（VEGF）level. Methods： 72 patients with advanced cervical cancer were randomly divided into two groups according to different treatment methods： TACE group and internal arterial infusion chemotherapy （IAIC）group, with 36 cases in each group. The clinical efficacy and the prognosis of patients were observed and compared. 36 healthy subjects were en- rolled as a control group at the same time. The levels of VEGF-A, VEGF-C, VEGF-D, VEGFR-2 and VEGFR-3 in serum were measured before and after treatment. Results： Patients with cervical cancer had higher levels of VEGF-A, VEGF-C, VEGF-D, VEGFR-2 and VEGFR-3 than the controls （P〈 0. 05）. After treatment, the levels of serum VEGF-A, VEGF-C, VEGF-D, VEGFR-2 and VEGFR-3 in TACE group and IAIC group were signifi- cantly decreased, and the decrease was more significant in the TACE group （P〈 0.05 ）. The total effective rate of TACE group was significantly higher than that of IAIC group （88. 89% vs. 69. 44%, P〈0. 05）. The 1-, 3- and 5-year survival rates in the TACE group were 97. 22%, 83. 33% and 75. 00% respectively, and were 80. 56%, 61. 11% and 50. 00% in the IAIC group. There were significant differences in the survival rates between the two groups （P〈0. 05）. Conclusion： TACE was effective for the treatment of advanced cervical cancer. It could inhibit the expression of VEGF and its receptor, and improve the prognosis of patients.
出处
《广西医科大学学报》
CAS
2017年第10期1460-1463,共4页
Journal of Guangxi Medical University
关键词
进展期宫颈癌
髂内动脉栓塞
动脉灌注化疗
血管内皮生长因子
advanced cervical cancer
trans-iliac-artery embolization
internal arterial infusion chemotherapy
vascular endothelial growth factor
