摘要
目的:探讨针刺调经促孕治疗对卵巢储备功能下降(DOR)患者卵巢功能的影响和安全性。方法:采用前瞻性病例序列研究的方法对46例DOR患者进行观察,最终纳入分析40例。取穴:(1)百会、神庭、关元及双侧本神、肓俞、大赫、卵巢、足三里、三阴交、太溪、太冲穴;(2)双侧肾俞、次髎穴。两穴组交替使用,隔日1次,每周治疗3次,12次为一疗程,共治疗3个疗程。于治疗前后及治疗结束3个月后随访时记录患者卵泡刺激素(FSH)、卵泡刺激素/黄体生成素(FSH/LH)、雌二醇(E_2)水平及窦卵泡计数(AFC)和中医症状评分,并对患者行安全性观察。结果:与治疗前比较,治疗后及随访时FSH水平、FSH/LH比值下降、E_2、AFC水平上升(均P<0.05)。治疗后及随访时中医症状评分均较治疗前显著下降(均P<0.05)。治疗后临床妊娠率为15%(6/40)。无感染、脏器损伤等发生。结论:针刺调经促孕治疗对DOR患者的卵巢储备功能具有良好的改善作用,且安全性较好。
Objective To investigate the effect and safety of acupuncture with regulating menstruation to promote pregnancy for diminished ovarian reverse（DOR）.Methods According to prospective case series,46 patients were observed and finally 40 cases were included.The acupoints were（1） Baihui（GV 20）,Shenting（GV 24）,Guanyuan（CV 4） and bilateral Benshen（GB 13）,Huangshu（KI 16）,Dahe（KI 12）,Luanchao（Extra）,Zusanli（ST 36）,Sanyinjiao（SP 6）,Taixi（KI 3）,Taichong（LR 3） and（2） bilateral Shenshu（BL 23） and Ciliao（BL 32）.The points in the two groups were used alternately.Acupuncture was given for 3 courses,12 times as a course and 3 times a week.Before and after treatment,and 3 months after treatment,follicle-stimulating hormone（FSH）,follicle-stimulating hormone/luteinizing hormone（FSH/LH）,estradiol（E2）,antral follicle count（AFC） and TCM symptom score were observed.The safety was evaluated.Results Compared with before treatment,the levels of FSH,FSH/LH decreased,and the levels of E2 and AFC increased after treatment and at follow-up（all P〈0.05）.And the TCM symptom scores were significantly lower than those before treatment（both P〈0.05）.The rate of pregnancy after treatment was 15%（6/40）.There was no infection and organ injury.Conclusion Acupuncture with regulating menstruation to promote pregnancy can safely improve the ovarian reserve of patients with DOR.
作者
李晓彤
许焕芳
房繄恭
尚洁
杨会生
周雪琳
张明龙
LI Xiaotong XU Huanfang FANG Yigong SHANG Jie YANG Huisheng ZHOU Xuelin ZHANG Minglong(Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China Department of Premature Ovarian Failure, Hospital of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700)
出处
《中国针灸》
CAS
CSCD
北大核心
2017年第10期1061-1065,共5页
Chinese Acupuncture & Moxibustion
基金
中国中医科学院基本科研业务费自主选题项目:ZZ 0908019
关键词
卵巢储备功能下降
针刺
病例序列研究
diminished ovarian reverse
acupuncture
prospective case series study
