摘要
肢端肥大症患者易合并肿瘤发生,尤其是甲状腺肿瘤和结直肠肿瘤。肢端肥大症肿瘤相关发病率和病死率总体上高于普通人群,其发病机制多与血清胰岛素样生长因子1(IGF-1)水平升高以及IGF-1信号通路激活相关。对肢端肥大症所致肿瘤合并症的早期筛查和干预可降低患者病死率。
Neoplasms are well known to be a complication in cases of acromegaly,especially thyroid and colorectal neoplasia. The incidence and mortality of neoplastic complications in acromegaly patients are higher than that of the general population,the pathogenesis of which is correlated with elevated serum levels of insulin-like growth factor 1（ IGF-1） and activation of IGF-1 signaling pathway. Early screening and intervention of neoplastic complications play an important role in decreasing the mortality of acromegaly patients.
作者
林蔚
郭晓鹏
幸兵
LIN Wei GUO Xiao-peng XING Bing(Dept. of Neurosurgery, Peking Union Medical College Hospital, CAMS ＆ PUMC, Beijing 100730, China)
出处
《基础医学与临床》
CSCD
2017年第10期1474-1477,共4页
Basic and Clinical Medicine
