摘要
本文采用磷酸二酯酶法测定了银屑病患者表皮和血清中钙调素(Calmodulin,CaM)含量,并报道了血清中无机磷的升高。健康人表皮CaM含量为0.45±0.09 μg/mg protein(16例),而患者未病变表皮含量为1.71±0.31 μg/mg protein(16例),病变表皮则更高为2.88±0.75μg/mg protein(16例)。血清CaM含量健康人为0.33±0.07 μg/mg protein(10例),患者为0.69±0.31μg/mg protein(9例)。血清无机磷含量健康人为0.04±0.01μg/mg (10例),患者则为0.13±0.06μg/mg(11例)。结果表明患者表皮和血清中CaM含量及血清无机磷含量显著升高。
The calmodulin content of the epidermis and serum in psoriasis was determined by using purified calmodulin and calmodulin-dificient phosphodiesterase from pig brain as a standard, and the content of inorganic phosphorus was also determined. Calmodulin content in the healthy human epidermis was 0.45±0.09 μg/mg protein (16), whereas it was significantly increased in psoriatic epidermis and 2.88±0.75 μg/mg protein (16) for the involved epidermis, respectively. In serum, calmodulin content was 0. 33±0.07 μg/mg protein (10) for the healthy humen and 0.69±0.31 μg/mg protein (9) for the psoriatic patients, respectively. In addition, inorganic phosphorus content was 0.04±0.01 mg/ml (10) for healthy humen serum and 0.13±0.06 mg/ml (11) for psoriatic patient serum, respectively. These results suggest that the elevation of calmodulin and inorganic phosphorus content may be related to the pathomechanisms of psoriasis.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1991年第2期89-92,共4页
Journal of China Pharmaceutical University
关键词
钙调素
无机磷
银屑病
表皮
血清
Calmodulin
Psoriasis
Inorganic phosphorus
Phosphodiesterase
Epidermis
Serum
