摘要
目的系统评价中医穴位敷贴治疗腹泻型肠易激综合征(IBS-D)的有效性及安全性。方法检索建库至2016年12月间CNKI、VIP、CBM、SCI、PubMed、Embase、Cochrane等中英文数据库中采用穴位敷贴治疗IBS-D的临床随机对照试验,并辅以手工检索。按照纳入排除标准筛选文献,Rev Man 5.3软件进行系统评价。结果 (1)最终纳入11项临床随机对照研究,合计803例患者,其中,穴位敷贴治疗组402例,西药对照组401例;(2)文献方法质量学方面,3分以上文献7篇,文献质量普遍较高;(3)有效性方面,与西医对照组相比,穴位敷贴治疗组临床总有效率的总优势比OR[95%CI]为3.29[2.25,4.82],差异有统计学意义(P<0.05)。其中,穴位使用频次前5位的依次是神阙、中脘、脾俞、足三里及肝俞穴;(4)安全性方面,除1项研究外,其余穴位敷贴治疗组不良反应发生率均低于西药对照组。结论穴位敷贴可以提高IBS-D临床效果且不良反应少,但仍需更多高质量的多中心、大样本随机对照试验证实。
Objective To systemic evaluate the efficacy and safety of Acupoint Application in the treatment of IBS-D. Methods The randomized controlled trials of Acupoint Application in the treatment of IBS-D were retrieved from Chinese and English databases, such as CNKI, VIP, CBM, SCI, PubMed, Embase, Cochrane from the date of establishment to December 2016. Manual retrieval was also employed as necessary. Relevant literatures were selected following inclusion and exclusion criteria and evaluated using RevMan 5.3 software. Results （1） A total number of eleven studies, including 803 patients, were enrolled, 402 patients received Acupoint Application therapy and 401 patients were received with Western medicine therapy. （2） In the aspect of literature methodology quality, seven articles scored above three, reflecting a relatively high literature se-lection criteria. （3） Clinical efficacy： In comparison with Western medicine, the clinical efficacy with OR [95% CI] of Acupoint Application therapy group was 3.29 [2.25, 4.82], which was statistically significant （P〈0.05）. Furthermore, the top five fre quently used points were Shenque, Zhongwan, Pishu, Zusanli and Ganshu point. （4） Safety： Despite one study favored west-ern medicine therapy, Acupoint Application therapy was well tolerated with manageable adverse effect. Conclusion Acupoint Application cwas effective and safe in treatment of IBS-D. However, more standardized multi center and large scale random-ized controlled trials are needed.
出处
《湖南中医药大学学报》
CAS
2017年第9期1002-1007,共6页
Journal of Hunan University of Chinese Medicine
基金
中国人民解放军第四军医大学西京医院临床高新技术项目(XJGX15Y38)
关键词
腹泻型肠易激综合征
穴位敷贴
随机对照试验
系统评价
diarrhea-predominant irritable bowel syndrome
acupoint application
randomized controlled trial
systematic review
