摘要
目的探讨益气活血汤联合西药治疗冠心病心绞痛的疗效,并分析其对血清炎症因子水平的影响。方法将冠心病心绞痛患者120例随机分为两组,每组60例。对照组患者给予西药常规治疗,观察组患者在对照组的基础上加用自拟益气活血汤。连续治疗8周后,对两组患者的疗效、血脂水平和血清炎症因子水平进行比较和分析。结果治疗8周后,观察组的总有效率为90.0%,显著高于对照组(78.3%),差异具有统计学意义(P<0.05);观察组的甘油三酯、总胆固醇和低密度脂蛋白水平均显著低于对照组,而高密度脂蛋白水平显著高于对照组,差异具有统计学意义(P<0.05);观察组的超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)和白细胞介素6(IL-6)水平均显著低于对照组,差异具有统计学意义(P<0.05)。结论益气活血汤联合西药治疗冠心病心绞痛疗效显著,患者血脂明显改善,血清炎症因子水平显著降低,值得临床推广。
Objective To explore the efficacy of Yiqi Huoxue decoction combined with Western medicine in the treat-ment of angina pectoris of coronary heart disease and its effect on level of serum inflammatory factors. Methods The 120 pa-tients with angina pectoris of coronary heart disease were randomly divided into two groups, 60 cases in each group. The control group was treated with conventional Western medicine treatment, and the patients in the observation group were given self-made Yiqi Huoxue decoction based on the control group. After 8 weeks of treatment, the efficacy, blood lipid level and serum inflammatory factor levels in the two groups were compared and analyzed. Results After 8 weeks of treatment, the total effective rate of the observation group was 90%, which was significantly higher than the control group （78.3%）, the difference was statistically significant （P〈0.05）. The triglycerides, total cholesterol and low density lipoprotein levels in observation group were significantly lower than the control group, and high density lipoprotein level were significantly higher than the con-trol group, the differences were statistically significant （P 〈0.05）. The high sensitivity C -reactive protein （hs -CRP）, tu-mor necrosis factor-α （TNF-α） and interleukin 6 （IL-6） levels in the observation group were significantly lower than the con-trol group, the differences were statistically significant （P〈0.05）. Conclusion Yiqi Huoxue decoction combined with West-ern medicine show obvious effect on angina pectoris of coronary heart disease, could improve blood lipid levels of patients, and lower the serum inflammatory factor levels significantly, which is worthy of clinical promotion.
出处
《湖南中医药大学学报》
CAS
2017年第9期969-972,共4页
Journal of Hunan University of Chinese Medicine
关键词
冠心病心绞痛
益气活血汤
血清炎症因子
临床研究
angina pectoris of coronary heart disease
Yiqi Huoxue Decoction
serum inflammatory factors
clinical study
