摘要
目的分析160例妊娠晚期亚临床甲状腺功能减退症(SCH)孕妇的妊娠及胎儿结局,为临床防治SCH提供参考依据。方法选取2014年1月-2016年10月银川市妇幼保健院收治的160例预行分娩的SCH孕妇作为观察组,另选取同期来院预行分娩的120例妊娠晚期无SCH的正常孕妇作为对照组。观察并比较两组孕妇的妊娠结局及胎儿结局。结果两组孕妇的贫血、妊娠期高血压疾病、妊娠期糖尿病、胎膜早破、先兆流产发生率比较,差异均有统计学意义(均P<0.05);两组孕妇的前置胎盘、低蛋白血症、胎盘早剥、肝内胆汁淤积症、产后出血发生率比较,差异均无统计学意义(均P>0.05)。两组胎儿宫内窘迫、早产发生率比较,差异均有统计学意义(均P<0.05);两组出生体质量、胎龄、胎儿宫内生长受限、胎儿畸形、新生儿窒息、死胎发生率比较,差异均无统计学意义(均P>0.05)。妊娠晚期合并SCH是孕妇贫血、妊娠期高血压疾病、妊娠期糖尿病、胎膜早破、先兆流产、胎儿宫内窘迫、早产等不良妊娠结局的危险因素。结论妊娠晚期SCH是导致不良妊娠结局的危险因素,孕妇发生贫血、妊娠期高血压疾病、妊娠期糖尿病、胎膜早破及先兆流产的风险较高,易引起胎儿宫内窘迫与早产。妊娠晚期SCH孕妇需及早接受干预治疗,以改善妊娠结局。
Objective To analyze pregnancy and fetal outcomes of 160 pregnant women with subclinical hypothyroidism （SCH） during the third trimester of pregnancy, provide a reference for clinical prevention and treatment of SCH. Methods A total of 160 pregnant women with SCH treated in the hospital from January 2014 to October 2016 were selected as observation group, and 120 normal pregnant women without SCH during the third trimester of pregnancy were selected as control group during the same period. The pregnancy and fetal outcomes in the two groups were observed and compared. Results There were statistically significant differences in the incidence rates of anemia, hypertensive disorder complicating pregnancy （HDCP） , gestational diabetes mellitus （GDM） , premature rupture of membrane （PROM）, threatened abortion between the two groups （ all P〈0. 05） . There was no statistically significant difference in the incidence rates of placenta previa, hypoproteinemia, placental abrnption, intrahepatie cholestasis of pregnancy, postpartum hemorrhage between the two groups （all P〉 0. 05 ） . There were statistically significant differences in the incidence rates of fetal distress and premature birth between the two groups （ both P〈0. 05 ） . There was no statistically significant difference in birth weight, gestational age, intrauterine growth restriction, fetal malformations, neonatal asphyxia, and stillbirth between the two groups （ all P〉0. 05 ） . SCH during the third trimester of pregnancy was one of the risk factors of adverse pregnancy outcomes, such as maternal anemia, HDCP, GDM, PROM, threatened abortion, fetal distress, and premature birth. Conclusion SCH during the third trimester of pregnancy is one of the risk factors of adverse pregnancy outcomes, the risks of maternal anemia, HDCP, GDM, PROM, threatened abortion are high among the pregnant women, fetal distress and premature birth often occur. SCH pregnant women during the third trimester of pregnancy should early receive interven6on and treatment to improve pregnancy outcomes.
出处
《中国妇幼保健》
CAS
2017年第18期4388-4391,共4页
Maternal and Child Health Care of China
关键词
妊娠晚期
亚临床甲状腺功能减退症
妊娠结局
胎儿结局
The third trimester of pregnancy
Subclinical hypothyroidism
Pregnancy outcome
Fetal outcome
