摘要
目的:探讨静吸复合麻醉对腹腔镜胆囊手术后全身创伤反应程度的影响。方法:收集在本院接受腹腔镜胆囊手术的慢性胆囊炎患者80例,回顾其麻醉方法并分为接受全凭静脉麻醉的对照组、接受静吸复合麻醉的观察组。术后6、12、24h,采用放射免疫法检测血清疼痛介质含量,采用酶联免疫吸附法(ELISA)检测血清炎症因子、应激激素含量,采用全自动凝血仪检测血浆凝血功能指标含量。结果:术后6、12、24h,观察组血清中疼痛介质5-HT、β-EP、NPY含量低于对照组,炎症因子hs-CRP、IL-6、IL-8、TNF-α含量低于对照组,应激激素Cor、ALD、NE含量低于对照组(P<0.05);观察组患者血浆中凝血功能指标TXB2、D-D、PLT含量低于对照组患者(P<0.05)。结论:静吸复合麻醉可减轻腹腔镜胆囊手术后全身创伤反应,具有积极的临床意义。
Objective; To study the effect of intravenous inhalational anesthesia under monitoring on systemic traumatic response after laparoscopic cholecystectomy. Methods： A total of 80 patients with chronic cholecystitis who underwent laparo- scopic cholecystectomy in our hospital were collected and divided into the control group who accepted total intravenous anesthe- sia and the observation group who accepted intravenous inhalational anesthesia after the anesthesia methods were retrospectively reviewed. Six, twelve and twenty-four hours after operation, the RIA method was adopted to determine the serum contents of pain mediators, enzyme-linked immunosorbent assay （ELISA） was used to determine serum levels of inflammatory factors and stress hormones, and auto-coagulation analyzer was used to detect the plasma contents of coagulation function indexes. Results, Six, twelve and twenty-four hours after operation, serum pain mediators 5-HT, β-EP and NPY levels of observation group were lower than those of control group, inflammatory factors hs-CRP, IL-6, IL-8 and TNF-α levels of observation group were lower than those of control group, and stress hormones Cor, ALD and NE levels of observation group were lower than those of control group （P〈0.05）; plasma coagulation function indexes TXB2, D-D and PLT levels of observation group were lower than those of control group （P〈0.05）. Conclusion： Intravenous inhalational anesthesia can reduce the systemic traumatic reac- tion after laparoseopic cholecystectomy and has positive clinical significance.
出处
《海南医学院学报》
CAS
2017年第15期2105-2108,共4页
Journal of Hainan Medical University
基金
陕西省教育厅专项科研计划项目(2013JK0795)
关键词
腹腔镜胆囊手术
静吸复合麻醉
疼痛介质
炎症因子
应激激素
Laparoscopic eholecystectomy
Intravenous inhalational anesthesia
Pain mediator
Inflammatory factor
Stress hormone
