摘要
阴道病又名阴道炎症,是妇科门诊多见和频繁发生的病症,具体指阴道黏膜及黏膜下相关组织的炎症。细菌性阴道病(bacterial vaginosis,BV)和假丝酵母菌性阴道病(candidal vaginitis,CV)是2种常见的阴道疾病,对女性的日常生活和学习造成了极大的影响。目前,对于BV和CV的治疗方法有了一定的改进和提升,从原来的西药或者抗生素治疗变为如今的完全中药方剂及中西药结合方剂治疗,并且在预防BV和CV方面也有了不错的发展。与西药或抗生素相比,中药可辨证论治,疗效稳定且较好、副作用极少,患者易接受。恢复正常的阴道微生物生态环境是治愈阴道病的根本,中药对阴道病的治疗恰好从这个目的出发,但可用于治疗BV和CV的中药材种类繁多且治疗机制复杂,本文通过查阅近年来的权威数据库中中英文文献,对BV和CV的发病机制、用于治疗BV和CV的常见中药以及中药治疗BV和CV的治疗机制进行阐述,以期为反复发作的BV和CV的治疗和新药研发提供新的思路。文章总结了BV的3种发病机制和CV发病机制的5个过程。通过统计,能够治疗BV的主要中药有123种,能够治疗CV的主要中药有133种,能够治疗这两种病的主要中药有84种,且治疗BV和CV的主要药用成分有生物碱、苷类、酚类、挥发油、绿原酸、黄酮类、色素、香豆素等。中药治疗BV和CV的机制:体外抑菌实验、其他抗菌药物渗透率增加、细胞内溶物外漏、机体免疫力提高、中西医结合治疗。文章最后对中药治疗BV和CV过程中存在的问题提出了相应的可行性建议。
Vaginal disease, which is also known as vaginal inflammation, is a common and frequent disease among gynecological outpatients. Specifically, it refers to the inflammation of vaginal mucosa and submucosa-related tissues. Bacterial vaginosis （BV） and candidal vaginitis （CV） are two common vaginal diseases, which cause great impacts on women＇s daily life and study. At present, therapies for BV and CV have been improved from previously western medicine or antibiotic therapy into today＇s complete traditional Chinese medicine （TCM） prescriptions and integrated TCM and western medicines. And there has been a good development in the prevention of BV and CV. Compared with western medicine or antibiotics, TCM can be applied based on syndrome differentiation, with a stable and better curative effect and less side effects, and thus being easily accepted by patients. The restoration of a normal vaginal microbial environment is the foundation for curing vaginal disease, which is the purpose of TCM in the treatment of vaginal diseases. However, there are many kinds of Chinese medicinal herbs that can be used to treat BV and CV, and the treatment mechanisms are complex. In this paper, we consulted Chinese and English literatures in authoritative databases in recent years, and discusses pathogenesis of BV and CV, common TCM for the treatment of BV and CV, and their treatment mechanism, in order to provide new ideas for treating recurrent BV and CV and new drug R＆D. The paper summarizes the three kinds of BV pathogenesis and five processes of CV pathogenesis. According to the statistics, there are 123 kinds of main TCM for treating BV, 133 kinds of main TCM for treating CV, and 84 kinds of main TCM for treating both diseases. And the main medicinal ingredients for treating BV and CV include alkaloid, glycosides, phenols, volatile oil, chlorogenic acid, flavonoids, pigments, and coumarin. TCM mechanisms for treating BV and CV are vitro antibacterial experiments, penetration increase of other antimicrobial agents, intracellular solution leakage, improvement of body immunity, and treatment with integrating traditional Chinese and western medicine. Finally, the paper shows some feasible suggestions on the problems existing in the treatment of BV and CV with TCM.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2017年第19期227-234,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
陕西省科技厅社会发展项目(2014K13-23)
秦巴山区生物资源综合开发协同创新中心项目(QBXT-Z(Y)-15-2)
陕西理工大学研究生创新基金项目(SLGYCX1721)
关键词
中药
细菌性阴道病
假丝酵母菌性阴道病
发病机制
治疗机制
研究进展
traditional Chinese medicine
bacterial vaginosis
candidal vaginitis
pathogenesis
treatment mechanism
advance of studies
