摘要
目的观察氯胺酮在抑郁症患者无抽搐电休克治疗(MECT)中的疗效。方法选择拟行无抽搐电休克治疗的抑郁症患者60例,年龄18~60岁,随机分为氯胺酮组和丙泊酚组,每组30例。在MECT前静注阿托品0.5~1.0mg、丙泊酚1.0mg/kg(丙泊酚组)或氯胺酮0.8mg/kg(氯胺酮组),待患者睫毛反射消失后静注琥珀胆碱0.7~1.0mg/kg。分别在第2、4、6次治疗后完成汉密尔顿抑郁量表(HAMD)。记录患者每次治疗时抽搐时间、抽搐指数、能量百分比、呼吸恢复时间及不良反应情况。结果随着治疗次数增加两组HAMD总分均明显下降(P<0.05)。氯胺酮组HAMD总分下降明显快于丙泊酚组(P<0.05)。两组患者抽搐时间、抽搐指数、能量百分比、呼吸恢复时间差异均无统计学意义。结论在抑郁症患者MECT治疗中氯胺酮降低HAMD评分的效果优于丙泊酚。
Objective To observe the effects of ketamine on the patients with depression receiving modified electric conulsive therapy（MECT）.Methods Sixty patients with depression were randomly divided into ketamine group and propofol group（n=30each group）.Atropine 0.5-1.0mg,propofol 1.0mg/kg or ketamine 0.8mg/kg i.v.were given before MECT,Scoline 0.7-1.0mg/kg i.v.was given after the eyelash reflex disappeared.Hamilton Depression Rating Scale（HAMD）was completed after the 2nd,4th and 6th MECT,the time of convulsion,twitch index,energy percentage,respiratory recovery time and adverse reactions were recorded.Results The total score of HAMD was significantly decreased with the increasing times of MECT in both groups,compared with propofol group,ketamine group＇s HAMD total score decreased faster,especially after the 4th MECT,the score decreased significantly in ketamine group（P〈0.05）.The time of convulsion,twitch index,energy percentage,respiratory recovery time,adverse reactions all had no statistical significance between the two groups.Conclusion Compered with propofol,ketamine,as an anesthetic of MECT,can effectively lower the score of HAMD.
作者
梅凤美
岳伟
曾琼
吴姗姗
高晓宁
朱美华
MEI Fengrnei YUE Wei ZENG Qiong WU Shanshan GAO Xiaoning ZHU Meihua(Department of Anesthesiology, Nanjing Brain Hospital, Nanjing 210029, China)
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2017年第9期864-867,共4页
Journal of Clinical Anesthesiology
关键词
氯胺酮
无抽搐电休克
抑郁症
Ketamine
Modified electric convulsive therapy
Depression
