摘要
目的:探讨冠状动脉造影慢血流患者的影响因素。方法:回顾性分析2008-01至2010-09于滨州医学院附属医院行冠状动脉造影检查的1 530例患者中的冠状动脉造影结果,入选患者根据校正的心肌梗死溶栓治疗临床试验(TIMI)后血流计帧数筛选出冠状动脉无明显狭窄但冠状动脉血流缓慢者139例为试验组,同期冠状动脉无明显狭窄且血流正常的患者232例作为对照组。统计常规临床实验室指标,比较两组患者的一般情况、实验室检查指标的差异、危险因素,并通过多因素Logistic回归分析冠状动脉慢血流的临床影响因素。结果:(1)两组患者比较,年龄、性别、吸烟史、糖尿病病史、红细胞、血红蛋白、平均红细胞血红蛋白浓度、红细胞压积、中性粒细胞、单核细胞、嗜碱性粒细胞、淋巴细胞/单核细胞、中性粒细胞/单核细胞、平均红细胞体积、红细胞分布宽度SD、中性粒细胞/淋巴细胞、血小板/淋巴细胞、谷草转氨酶、肌酸激酶及总胆汁酸差异均有统计学意义(P<0.05)。(2)相关分析显示,红细胞(r=0.191,P<0.01)、血红蛋白(r=0.184,P<0.01)、中性粒细胞(r=0.218,P<0.01)、平均红细胞血红蛋白浓度(r=0.151,P<0.01)、平均红细胞体积(r=-0.138,P<0.01)、总胆汁酸(r=-0.172,P<0.01)、中性粒细胞/淋巴细胞(r=0.231,P<0.01)、淋巴细胞/单核细胞(r=-0.157,P<0.01)、中性粒细胞/单核细胞(r=0.121,P<0.01)与三支平均血流帧数显著相关。(3)多因素Logistic回归分析显示,总胆汁酸(偏回归系数=-0.102,P<0.01)、淋巴细胞/单核细胞(偏回归系数=-0.381,P<0.01)、中性粒细胞/单核细胞(偏回归系数=0.489,P<0.01)是冠状动脉慢血流的独立影响因素。结论:总胆汁酸、淋巴细胞/单核细胞、中性粒细胞/单核细胞是冠状动脉慢血流的影响因素。
Objective： To investigate the influencing factors of coronary slow flow （CSF） in relevant patients. Methods： A total of 1 530 patients received coronary angiography （CAG） in our hospital from 2008-01 to 2010- 09 were retrospectively studied. According to corrected TIMI frame counts, 2 groups were established： CSF group, n-139 patients without obvious coronary artery stenosis but with CSF and Control group, n=232 patients without obvious coronary artery stenosis and with normal coronary blood flow. Basic clinical condition, risk factors and routine laboratory tests were compared between 2 groups; the influencing factors of CSF were evaluated by multivariate Logistic regression analysis. Results： ① The following parameters were different between 2 groups： age, gender, histories of smoking and diabetes; red blood cells （RBC）, hemoglobin, mean hemoglobin concentration, hematocrit （HCT）, mean RBC volume, RBC distribution width; neutrophils, monocytes, basophilic granulocyte, the ratios of lymphocytes/monocytes （LMR）, neutrophils/ monocytes （NMR）, neutrophils/lymphocytes （NLR） and platelet/lymphocytes （PLR）; glutamic oxalacetic transaminase, creatine kinase and total bile acid, P〈0.05. ② Correlation analysis showed that RBC （r=0.191, P〈0.01）, hemoglobin （r=0.184, P〈0.01）, neutrophils （r=0.218, P〈0.01）, mean hemoglobin concentration （r=0.151, P〈0.01）, mean RBC volume （r=-0.138,P〈0.01）, total bile acid （r=-0.172, P〈0.01）, NLR （r=0.231, P〈0.01）, LMR （r=-0.157, P〈0.01） and NMR （r=0.121, P〈0.01） were related to 3-branch mean flow frame. ③ Multivariate Logistic regression analysis indicated that total bile acid （partial regression coefficient=-0.102, P〈0.01）, LMR （partial regression coefficient =-0.381, P〈0.01） and NMR （partial regression coefficient =0.489, P〈0.01） were the independent influencing factors of coronary slow flow. Conclusion： Total bile acids, LMR and NMR were the influencing factors of coronary slow flow in relevant patients.
出处
《中国循环杂志》
CSCD
北大核心
2017年第9期877-881,共5页
Chinese Circulation Journal
基金
山东省科技发展计划医药卫生项目(2013TD18019)
山东省医药卫生科技计划(2015BJYB31)
滨州市科技发展计划(2015ZC0315)
