摘要
目前,冠状动脉粥样硬化性心脏病(冠心病)正威胁着患病人群的生活质量,甚至生命安全。科学家一直在寻找治疗冠心病更有效、更全面的药物,既可以缓解不稳定型心绞痛的症状,又能在冠心病再灌注损伤方面起到有效的心肌保护作用,使患者的远期预后得到明显改善。尼可地尔是一种类硝酸酯化合物,不仅拥有硝酸酯类药物的扩张冠状动脉作用,还具有开放心脏钾离子通道的独特作用,现已广泛应用于冠心病的临床治疗。今后,期望其在治疗心绞痛、心肌梗死、心力衰竭方面有新的应用。
Currently, coronary atherosclerotic heart disease is threatening the quality of life of the affected population and even life safety. Scientists have been searching for more effective and comprehensive drugs for the coronary heart dis- ease,which can alleviate the symptoms of unstable angina, provide myocardial reperfusion injury protection for coronary heart disease, and improve long-term prognosis of the patients obviously. Nicorandil, is a type of nitrate ester compounds, not only has the dilating coronary artery effect, but also has the unique function of opening heart potassium channels, and has been widely used in clinical to treat coronary heart disease. In the future, we hope that it can be used in the treatment of anginapectoris, myocardial infarction and heart failure.
作者
梁泽尚
李永东
LIANG Zeshang LI Yongdong.(Department of Cardiology, the Third Affiliated Hospital of Inner Mongolia Medical University,Baotou 014010, China)
出处
《医学综述》
2017年第18期3625-3629,共5页
Medical Recapitulate
关键词
冠心病
尼可地尔
心肌保护
Coronary heart disease
Nicorandil
Myocardial protection
