摘要
目的探讨舒腹散对老年脓毒症患者胃肠道功能的保护作用。方法选取2014年3月至2016年9月期间收治的老年脓毒症患者168例,对照组84例予以常规西医治疗,治疗组84例在对照组基础上予以舒腹散治疗,观察比较两组间胃肠功能相关指标及预后情况。结果对照组治疗有效率(61.90%)低于治疗组治疗有效率(76.19%),具有统计学意义(P<0.05);治疗组治疗后急性生理学及慢性健康状况评分(APACHEⅡ)、胃残留量(GRV)、腹腔内压力(IAP)水平较低,血清胃动素(MOT)及胃黏膜p H值(pHi)水平较高,胃泌素(GAS)、血清超敏C反应蛋白(hs-CRP)、降钙素原(PCT)及血浆D-乳酸(D-Lac)水平较低,住院时间、MODS发生率及28 d死亡率较低,均具有统计学意义(P<0.05)。结论舒腹散能提高西医常规疗法治疗老年脓毒症患者的临床疗效,保护胃肠功能。
Objective To investigate the protective effect of Shufu San on gastrointestinal function in elderly patients with sepsis. Methods 168 elderly patients with sepsis from March 2014 to June 2016 are selected as research objects,and they are randomly divided into control group and treatment group by random number table method.The control group is just treated with conventional western medicine treatment, the treatment group is received with Shufu San on the basis of the control group. Observed the related parameters of gastric bowel function and prognosis between the two groups. Results The effective rate in the control group（61.90%） is lower than the experiment group（76.19%）, two way before and after treatment in comparison with statistical significance （P 〈 0.05）; compare with the control group, the acute physiology and chronic health evaluation scoring, GRV, lAP levels are lower in the experiment group after treatment, serum MOT and pHi levels are higher, GAS level is lower after treatment, serum levels of hs-CRP, PCT and plasma level of D-Lac are lower after treatment, length of stay, the incidence of Multiple organ dysfunction syndrome（MODS）, and 28 d mortality are lower, with significant difference （P 〈 0.05）. Conclusion Shufu San can improve the clinical efficacy of conventional western medicine therapy in the treatment of elderly patients with sepsis, protect the gastrointestinal function.
出处
《现代中药研究与实践》
CAS
2017年第4期72-76,共5页
Research and Practice on Chinese Medicines
关键词
脓毒症
老年患者
舒腹散
胃肠道功能
保护
sepsis
elderly patients
Shufu San
gastrointestinal function
protection
