摘要
目的探讨系统性红斑狼疮(SLE)并发侵袭性真菌病(IFD)的临床特征。方法对2009年1月-2013年12月在本科住院的803例SLE患者临床资料进行分析,比较合并IFD与未合并IFD患者的临床特点。结果 SLE并发IFD者27例,没有确诊的病例;从27例IFD患者中分离到33株真菌,其中白念珠菌30株(90.91%)、光滑念珠菌2株、克柔念珠菌1株,标本分别来源于下呼吸道、消化道和泌尿道;抗真菌治疗均有效。疑似感染症状,SLEDAI≥9,CRP≥0.8mg/d L为SLE合并IFD的独立危险因素。结论本科SLE并发IFD的患者发生率为3.36%,致病菌以白念珠菌为主,氟康唑是有效的抗真菌治疗药物之一。
Objective To analyze the clinical features of the patients with systemic lupus erythematosus（SLE） accompanied with invasive fungal disease（IFD）. Methods Data of 803 SLE inpatients were researched, ranging from January 2009 to December 2013, who were adopted in our department. Clinical data of two groups were compared to reveal the clinical features of SLE accompanied with IFD and without IFD. Results There were 27 cases of SLE with IFD, no patients were confirmed as IFD. There were 33 strains fungi isolated from the 27 patients with IFD, included 30 strains（90. 91% ） Candida albicans, 2 strains Candida glabrata and 1 strain Candida krusei. The 33 strains fungi were identified from lower respiratory tract, gastrointestinal tract and urinary tract of the 27 IFD patients. The antifungal treatment was effective. Suspected infection symptoms, the score of SLEDAI≥ 9, CRP ≥ 0. 8mg/dL were independent risk factors of SLE accompanied with IFD. Conclusion For SLE patients admitted in our department, the incidence of accompanying IFD is 3.36% , Candida albicans is the main pathogen and fluconazole is one of the effective treatments.
出处
《中国皮肤性病学杂志》
CSCD
北大核心
2017年第9期980-983,共4页
The Chinese Journal of Dermatovenereology
基金
云南省科技厅-昆医联合项目
关键词
系统性红斑狼疮
侵袭性真菌病
Systemic lupus erythematosus
Invasive fungal disease
