摘要
目的:观察黄芪对于慢性宫内缺氧诱导的子代兔非酒精性脂肪肝的肝功能、血脂及病理的影响。方法:将健康孕兔随机分为对照组、模型组、黄芪组,建立宫内缺氧模型,黄芪组给予黄芪注射液干预,对照组、模型组耳缘静脉注射生理盐水。待分娩后,检测6月龄子代雄兔肝功能、血脂及肝组织病理改变。结果:与模型组比较,黄芪组脂肪变性程度显著减轻(P<0.01);血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)降低,高密度脂蛋白(HDL-C)增高(P<0.01)。结论:黄芪能够在一定程度上减轻慢性宫内缺氧引起的子代兔肝细胞脂肪变性。
Objective：To investigate the effect of chronic intrauterine hypoxia on nonalcoholic fatty liver disease in adult rabbit offspring and the protective function of Astragalus. Methods：The pregnant rabbits were randomly divided into normal control group,Astragalus group and model group. After delivery,one male offspring rabbit per litter was selected and divided into 3 groups respectively.At sixth month of age,serum alanine transaminase（ALT）、aspartate transaminase（AST）、triglyceride（TG）、cholesterol（TC）、low density lipoprotein-cholesterol（LDL-C）,high density lipoprotein-cholesterol（HDL-C）were measured.The pathological changes of liver tissue were observed. Results：Compared with model group,the level of serum TG、TC、LDL-C in Astragalus group were significantly decreased,but the level of serum HDL-C was increased in Astragalus group（P0.01）. The degree of hepatic steatosis observed under light microscope by HE staining technique was weakened in Astragalus group. Conclusion：Astragalus can reduce the damage of nonalcoholic fatty liver disease in adult rabbit offspring which is caused by chronic intrauterine hypoxia.
出处
《山西中医学院学报》
2017年第3期9-11,共3页
Journal of Shanxi College of Traditional Chinese Medicine
基金
国家自然科学基金(81271587)
关键词
脂肪肝
慢性宫内缺氧
黄芪
保护作用
fatty liver
chronic disease
Astragalus
protective effect
