摘要
目的:探讨枸橼酸咖啡因不同使用时机对早产儿呼吸支持的影响。方法:收集使用有创呼吸机治疗的早产儿66例,随机分为两组。A组出生后24~72 h开始使用枸橼酸咖啡因;B组出生后>72 h,撤呼吸机前24 h内开始使用枸橼酸咖啡因。比较两组机械通气、CPAP、用氧、咖啡因等使用时间及呼吸暂停发生等情况。结果:A组机械通气时间及总用氧时间均短于B组(P<0.05);两组使用CPAP及咖啡因时间比较差异无统计学意义(P>0.05);A组拔管后24 h内呼吸暂停的发生率少于B组(P<0.05)。两组支气管肺发育不良的发生率比较差异无统计学意义(P>0.05)。结论:对需机械通气治疗的早产儿,早期使用枸橼酸咖啡因可缩短机械通气时间及用氧时间,减少拔管后呼吸暂停的发生。
Objective：To investigate the influence different timing of caffeine citrate therapy on respiratory support in preterm infants.Methods：A total of 66 preterm infants with invasive mechanical ventilation were randomized into 2 groups：Group A and B.Caffein citrate was administered in preterm infants in group A at24 to 72 hours after birth,while in group B 72 h after birth.Within 24 hours before extubation,the same dosage of caffein citrate began to be used to infants in both groups.Length of mechanical ventilation,CPAP,total duration of oxygen therapy,caffein citrate therapy,and apnea were compared between infants in the two groups.Results：Compared with the group B,group A had significantly shorter duration of mechanical ventilation and oxygen therapy（P〈0.05）.However,there were no significant difference in the duration of CPAP and caffein citrate therapy between the two groups（P〉0.05）.In addition,group A had significantly lower incidence of apnea 24 hours after extubation（P〈0.05）than that of group B（P〈0.05）,but there was no significant difference in the incidence of BPD in both groups（P〈0.05）.Conclusion：Earlier initiation of caffeine citrate therapy may be associated with the reduction in duration of ventilation and oxygen therapy in preterm infants with mechanical ventilation,and the reduction of apnoeic attacks after extubation as well.
出处
《华夏医学》
CAS
2017年第4期25-28,共4页
Acta Medicinae Sinica
基金
广西卫计委科研课题项目资助(Z2014499)
关键词
咖啡因
使用时机
呼吸支持
早产儿
caffeine
timing of drug therapy
respiratory support
preterm infants
