摘要
目的评价醒脑静注射液联合盐酸纳洛酮注射液治疗急性脑出血伴昏迷患者的临床效果。方法通过检索PubMed、Cochrane Library、Embase、PEDro、NTIS、CNKI、Wanfang Data、VIP等数据库,以"醒脑静""纳洛酮""脑出血""昏迷""晕厥""意识障碍"为检索词,检索所有关于醒脑静注射液联合盐酸纳洛酮注射液治疗急性脑出血伴昏迷患者的随机对照试验(RCTs),检索时间为建库至2017年5月,采用Rev Man5.3软件进行Meta分析。结果共纳入10项RCTs,916例患者。Meta分析结果显示,联合用药可提高治疗总有效率[OR=3.37,95%CI(2.04,5.56)],患者脑血肿面积明显缩小[OR=-3.75,95%CI(-6.61,-1.34)],患者GCS评分比常规治疗评分高[OR=2.87,95%CI(2.27,3.48)],NHISS评分改善程度优于对照组[OR=-6.05,95%CI(-7.88,-4.22)]。结论联合用药治疗急性脑出血伴昏迷患者的效果显著,具有很好的协同作用和效果,临床应用价值较大。
Objective To evaluate therapeutic efficacy of Xingnaojing Injection combined with Naloxone Injection in the treatment of acute cerebral hemorrhage patients with coma. Methods Ran domized controlled trials of the therapeu- tic efficacy of Xingnaojing Injection combined with Naloxone Injection in the treatment of acute cerebral hemorrhage patients with coma, PubMed, Cochrane Library, Embase, PEDro, NTIS, CNKI, Wanfang Data, VIP were collected （from the establilshment to May 2017）. Key words including ＂Xingnaojing＂, ＂Naloxone＂, ＂Cerebral Hemorrhage＂, ＂Coma＂, ＂Syncope＂, ＂Consciousness＂. Meta-analysis was performed by RevMan 5.3 software. Results A total of 10 RCTs were screened, which 916 patients were included. Meta analysis showed that the combined drugs can improve total effective rate of treatment [OR = 3.37, 95%CI（2.04, 5.56）],significantly reduced cerebral hematoma area [OR = -3.75, 95%CI（-6.61, -1.34）], patients GCS score was higher than the conventional treatment score [OR=2.87, 95%CI（2.27, 3.48）], the improvement degree of NHISS score was better than that of control group [OR=-6.05, 95%CI（-7.88, -4.22）]. Conclusion Combination therapy is effective in the treatment of acute cerebral hemorrhage accompanied with coma, and have a batter synergistic effect and clinical application value.
出处
《中国医药导报》
CAS
2017年第23期13-17,共5页
China Medical Herald
基金
湖北省教育厅人文社会科学研究项目(16Y124)
湖北省教育厅科学研究计划指导性项目(B2016503)
关键词
醒脑静
纳洛酮
脑出血
META分析
Xingnaojing
Naloxone
Cerebral hemorrhage
Meta analysis
