摘要
目的 :探讨核有丝分裂器蛋白 (NMP 2 2 )在诊断膀胱癌中的临床应用价值。方法 :选择可疑膀胱癌患者 70例 ,应用美国MatritechNMP 2 2试剂盒检测尿中NMP 2 2的含量 ,同时行尿脱落细胞学检查并进行对比。结果 :膀胱癌组与非膀胱癌组患者尿中NMP 2 2值分别为 (5 5 .84± 4 7.89)× 10 3U L、(15 .5 8± 17.73)× 10 3U L ,差异有极显著性意义 (P <0 .0 1) ,且膀胱癌组NMP 2 2水平与肿瘤分期分级有关。当以 14× 10 3U L作为诊断参考值时 ,NMP 2 2诊断膀胱癌的敏感度为 90 .6 3% ,特异度为 76 .32 %。结论 :NMP 2 2诊断膀胱癌具有简单、无创伤、敏感度高、可定量分析等优点 。
Purpose:To study the clinical significance of the nuclear mitotic apparatus protein for diagnosis of bladder cancer. Methods:70 cases of selected patients with clinical suspicious bladder cancer underwent voided urine NMP22 tests and cytology. Results:The NMP22 level was significantly higher in bladder cancer group ( 55.84 ± 47.89 ×10 3 U/L) than that in non bladder cancer group ( 15.58 ± 17.73 ×10 3 U/L). Urinary NMP22 values was also related to tumor staging and grading. NMP22 at a cutoff value of 14×10 3 U/L) showed a sensitivity of 90.63 % and specificity of 76.32 %, while cytology had a sensitivity of only 25.0 % and specificity of 100%. Conclusions:Urinary NMP22 is a simple, noninvasive, quantitative, sensitive test for the diagnosis and surveillance of bladder cancer.
出处
《临床泌尿外科杂志》
2002年第8期422-423,426,共3页
Journal of Clinical Urology
