摘要
目的 观察头孢哌酮舒巴坦对脓毒血症患者疗效及炎症因子的影响。方法 选取2014年1月-2015年4月江油市903医院呼吸内科收治的80例脓毒血症患者,采用双盲、随机的方法将分为对照组39例和观察组41例。对照组采用常规治疗方法,观察组采用头孢哌酮舒巴坦进行治疗。结束治疗后,对2组患者白细胞介素IL-6、IL-10、IL-1和C-反应蛋白（CRP）的水平以及治疗疗效进行对比分析。结果 治疗后,观察组患者的IL-6、IL-10、IL-1、CRP水平均低于对照组（t=15.555;t=11.122;t=9.379;t=34.782）,差异有统计学意义（P〈0.05）;观察组的患者总有效率为95.12%,明显高于对照组76.93%,且差异有统计学意义（P〈0.05）;观察组患者治疗后无痛和剧烈疼痛比例明显低于对照组76.93%,且差异有统计学意义（P〈0.05）。结论 头孢哌酮舒巴坦对脓毒血症患者有显著的改善作用,可提高患者治疗疗效,是一种安全且有效的治疗方法,应在临床中进行推广和使用。
Objective To observe the effect of cefoperazone sulbactam on the efficacy inflammatory factors in patients with sepsis. Methods 80 cases of sepsis patients from January 2014 to April 2015, were double-blindly, randomized divided into control group（41 cases） and observation group（39 cases）. The control group was treated with conventional treatment methods, the observation group was treated with cefoperazone sulbactam. After treatment, Leukocyte IL-6, IL-10, IL-1 and C- reactive protein （CRP） levels of interleukin and curative effect in the two groups were analyzed. Results After treatment, the levels of IL-6, IL-10, IL-1, CRP in the observation group were lower than those in the control group （t=15.555;t=11.122; t=9.379; t=34.782）, the difference was statistically significant （P〈0.05）; The total effective rate in the observation group was 95.12%, which was significantly higher than that in the control group （76.93%）, and the difference was statistically significant （P〈0.05）; The proportion of painless and severe pain in the observation group was significantly lower than that in the control group（76.93%）, and the difference was statistically significant （P〈0.05）. Conclusion Cefoperazone sulbactam is effective in the treatment of sepsis, can improve the efficacy of treatment, it is a safe and effective treatment, should be promoted and used in clinical.
出处
《中国生化药物杂志》
CAS
2017年第8期257-258,261,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
头孢哌酮舒巴坦
脓毒血症
疗效
炎症因子
cefoperazone and sulbactam
sepsis
efficacy
inflammatory cytokines
