摘要
对50例充血性心力衰竭患者(CHF)及44例健康者进行了血过氧化脂质(LPO)、超氧化物歧化酶(SOD)的检测。结果发现,心力衰竭患者的LPO、血清及红细胞内SOD活力较对照组显著升高;随着心力衰竭加重,LPO、SOD皆增加,SOD/LPO比值下降,LPO含量与心功能呈显著负相关,心力衰竭改善,LPO及SOD减少,SOD/LPO上升。这表明脂质过氧化增强在CHF的发生发展过程中可能起着重要的促进作用,LPO、SOD动态变化可作为判断心力衰竭程度的参考指标。
Serum lipid peroxide (LPO), serum and erythrocyte superoxide disumtase (SOD and SOD_(RBC)) activity were determined in 50 cases with congestive heart failure (CHF group) and 44 healthysubjects (control group). The results indicated statistically significant increase of LPO, SOD and SOD_(RBC), and statistically significant decrease of SOD/LPO in CHF group as compared with control group. Regression analysis showed negative correlation between LPO and cardiac function in CHF group. Improvement of CHF was accompanied by statistically signifiant increase lof SOD/LPO, and statistically significant decrease of LPO, SOD and SOD_(RBC). The findings implicate that lipid peroxidation may play an important role in the pathogenesis and development of CHF. Parameters of lipid peroxidation might be used as criteria for judging the degree of CHF.
出处
《中国循环杂志》
CSCD
1991年第5期376-378,共3页
Chinese Circulation Journal
关键词
心力衰竭
脂质过氧化
充血性
Lipid peroxides
Superoxide dismutase
Congestive heart failure
