摘要
目的:对比分析静脉滴注尼莫地平和口服尼莫地平治疗蛛网膜下腔出血后脑血管痉挛的临床疗效。方法:选取某院2015年2月~2016年2月收治的48例蛛网膜下腔出血后脑血管痉挛患者,采用随机数字表法分为对照组和观察组。对照组患者采用口服尼莫地平治疗,观察组患者采用静脉滴注尼莫地平治疗。对比两组患者血管再痉挛率、再出血率以及死亡率,并将两组患者治疗前后的神经功能缺损评分进行比较。结果:两组患者血管再痉挛率、再出血率以及死亡率均较低,组间比较无明显差异(P>0.05);治疗后两组患者神经功能缺损评分均比治疗前低(P<0.05),且观察组患者的神经功能评分比对照组更低,但差异不具有统计学意义(P>0.05)。结论:尼莫地平静脉滴注与口服均可有效改善患者神经功能,患者血管再痉挛率、再出血率以及死亡率均较低。
Objective：To compare and analyze the clinical effects of intravenous infusion of nimodipine and oral nimodipine in the treatment of cerebral vasospasm after subarachnoid hemorrhage.Methods：48 cases of patients with cerebral vasospasm after subarachnoid hemorrhage treated in a hospital from February 2015 to February 2016 were selected,and were randomly divided into control group and observation group.Patients in the control group were treated with oral nimodipine while patients in the observation group were treated with intravenous injection of nimodipine.Then,the vascular spasm rate,re bleeding rate,and mortality rate of two groups of patients were compared,and the neurological deficits scores of two groups before and after treatment were compared.Results：The rate of vasospasm,the rate of re bleeding and mortality of groups of patients were both lower,and there was no significant difference between the groups（P〉0.05）;the neurological deficit scores of two groups were lower than that of before treatment（P〈0.05）,and the neurological deficit scores of observation group was lower than that of the control group,but the difference was not statistically significant（P〉0.05）.Conclusion：The intravenous infusion and oral administration of nimodipine can both effectively improve the patient＇s neurological function,and the vascular spasm rate,re bleeding rate and mortality rate of patients were lower.
出处
《数理医药学杂志》
2017年第8期1203-1204,共2页
Journal of Mathematical Medicine
关键词
尼莫地平
蛛网膜下腔出血
脑血管痉挛
不同给药方式
临床疗效
nimodipine
subarachnoid hemorrhage
cerebral vasospasm
different ways of administration
clinical effect
