摘要
冠状动脉粥样硬化性心脏病现成为心血管疾病中最主要同时也是危害性最大的疾病。随着临床研究的不断进展,冠心病的治疗已经进入了介入治疗和药物治疗相结合的阶段。经皮冠状动脉介入治疗和药物治疗的最终目的是尽快开通梗死相关的冠脉,尽快恢复心肌组织再灌注。但冠状动脉大血管的再通,并不等于心肌组织有效的再灌注。冠状动脉结构和功能完整是实现心肌再灌注的前提。许多临床研究发现,经皮冠状动脉介入治疗和药物治疗后仍有部分心肌组织不能得到充分有效灌注,这种现象与冠心病内皮细胞功能的损伤有着十分密切的关系。本文通过深入研究内皮细胞功能损伤与冠心病之间的危险关系,完善内皮细胞功能损伤与冠心病的作用机理,探索如何通过干预内皮细胞功能的损伤,治疗及预防冠心病的发生、发展和预后,为临床冠心病的防治开辟新的方向。
Now,Coronary heart disease is the most important cardiovascular disease.And it is also the greatest danger of the disease in China.With clinical research progresses,the treatment of coronary heart disease has entered a drug treatment intervention and a combination of stage.The ultimate goal of PCI and drug is that open infarct-related coronary artery and reply myocardial reperfusion as soon as possible.However,recanalization of the large vessels coronary does not mean that effective myocardial reperfusion.To achieve myocardial reperfusion premise is keeping coronary artery structure and function completely.Many clinical studies found,it is still part of the myocardial tissue perfusion can not be fully effective after PCI and drug treatment.This phenomenon is closely related with coronary endothelial dysfunction.So,we need further research risk relationship between endothelial dysfunction and coronary heart disease,improve endothelial dysfunction and coronary heart disease of mechanism.To explore how treatment and prevention development and prognosis of coronary heart disease by interfering injury endothelial function,it will open a new direction for preventing and treating coronary heart disease.
出处
《青岛医药卫生》
2017年第4期305-308,共4页
Qingdao Medical Journal
