摘要
心肌预先反复短暂缺血及维拉帕米(异搏定)均可抑制急性心肌梗塞(AMI)再灌注后血小板聚集功能的增强及血浆TXB_(1)水平的增高反应,并缩小其梗塞范围。但在心肌预先反复缺血的基础上,维拉帕米却无上述效应。
The effects of repetitive brief episodes of ischemia and verapamil on acute myocardial infarc-tion-reperfusion(AMI-R)were studied.Rabbits were divided into 4 groups.Group A and B received 60 min.coronary occlusion.Group C and D were preconditioned with three 5 min.coronary occlusions separated by 15 min.of reperfusion,followed by a sustained 60 min.occlusion.All rabbits were allowed 180 min.of reperfusion thereafter.Group A and C were controls.Group B and D received verapamil(1 mg/kg)before ischemia.The results showed that platelet aggregation(PAg),circulating platelet aggregates(CPA)and plasma TXB:level increased significantly after AMI-R(groupA).Verapamil(group B)and preconditioning with repetitive ischemia(group C)could inhibit the increasing reaction and limit infarct slze(IS)respectively.But verapamil could neither further limit IS nor inhibit the increase of PAg,CPA and plasma TXB_2 level after AMI-R preconditioned with repetitive ischemia.
出处
《中国循环杂志》
CSCD
1991年第4期294-296,共3页
Chinese Circulation Journal
关键词
反复短暂心肌缺血
维拉帕米
急性心肌梗塞再灌注
Repetitive myocardial ischemia
Verapamil
Acute myocardial infarctionreperfusion
