摘要
目的探究不同剂量蒽环类药物对乳腺癌术前化疗的效果。方法针对40例乳腺癌患者使用小剂量蒽环类药物治疗,并归为对照组,针对另外40例患者使用大剂量蒽环类药物治疗,并归为观察组,此后观察2组患者情况并进行比较;入选患者均为曲沃县人民医院2016年1月~2016年12月间收治。结果观察组治疗总有效率为82.5%,对照组总有效率为62.5%,2组比较患者的治疗效果比较差异有统计学意义（P〈0.05）;观察组患者不良反应发生率为0,对照组总不良反应发生率为27.5%,2组不良反应发生率比较差异具有统计学意义（P〈0.05）。结论不同剂量蒽环类药物对乳腺癌术前化疗临床效果探讨发现,不同剂量所产生的临床效果不同,就E_（100）C和E_（75）C而言,E_（100）C能够提高患者的治疗效果,同时减少不良反应的发生,因此值得临床借鉴。
Objective To explore the effect of different doses of anthracycline on preoperative chemotherapy of breast cancer. Methods In 40 cases of breast cancer patients using small doses of anthracycline therapy,and classified as the control group,the other 40 patients using high-dose anthracycline therapy,and classified as observation group. Then observe two groups of patients were compared; the patients were in our hospital from January to December 2016 were treated. Results The total effective rate was 82. 5% in the observation group and 62. 5% in the control group,the difference between the two groups was statistically significant（ P〈 0. 05）. The incidence of adverse reactions in the observation group was 0,the control group was 27. 5%,and the incidence of adverse reactions in the two groups was statistically significant（ P〈 0. 05）. Conclusion Different doses of anthracyclines on the clinical effect of chemotherapy before surgery for breast cancer research found that different the clinical effect of different doses produced by E100C and E75C,E100C can improve the treatment effect of the patients,and reduce the occurrence of toxicity,so it is worthy of reference.
出处
《中国生化药物杂志》
CAS
2017年第7期194-195,共2页
Chinese Journal of Biochemical Pharmaceutics
关键词
不同剂量
蒽环类药物
乳腺癌
术前化疗
临床效果
different doses
anthracycline
breast cancer
preoperative chemotherapy
clinical effect
