摘要
目的用功能磁共振构建功能脑网络,检测伴有抑郁的MCI(MCI-d)患者的脑功能连接强度(FCS)的变化,并进一步探测抑郁与AD之间的关系。方法共纳入27例不伴有抑郁的MCI患者(MCI-nd),19例伴有抑郁的MCI患者(MCI-d)及32例年龄、性别和受教育程度相匹配的健康对照者(HC)。采集所有受试的功能磁共振(fMRI)数据,对数据进行常规预处理,构建基于脑图谱AAL-1024模板分区的脑功能网络,计算各脑区的FCS及核心节点(hub),比较3组在FCS上的差异,然后确定差异脑区及其功能连接特征。结果 HC与MCI-nd之间有差异的脑区(P<0.005):左脑背外侧额上回(FCS增强)、右脑楔前叶(FCS减弱);HC与MCI-d之间有差异的脑区(P<0.005):右脑颞下回(FCS减弱)、右脑背外侧额上回(FCS减弱)、左脑颞中回(FCS减弱)、右脑角回(FCS减弱);MCI-nd与MCI-d之间有差异的脑区(P<0.005):左脑额中回(FCS减弱)、右脑额中回(FCS减弱)、左脑角回(FCS减弱)、右脑角回(FCS减弱)。其中左脑颞中回、右脑角回为核心节点。结论情感网络和默认网络在MCI-d中可能同时受损,提示抑郁有可能是临床前期AD的一个潜在的临床标志,可用于识别最有可能进展为AD的MCI。
Objective To construct functional brain network by functional magnetic resonance imaging （fMRI） to detect the changes of brain functional connectivity in mild cognitive impairment with depression （MCI -d） , and to explore the relationship between depres- sion and Alzheimer＇s desease （AD）. Methods This study included 27 patients with MCI who were not associated with depression （MCI- nd） , 19 MCI with depression （MCI -d） and 32 healthy controls （HC） matched for age, sex and education level. Firstly, all subjects were collected for functional magnetic resonance （fMRI） data, then brain functional networks were constructed based on AAL- 1024 template partition. Secondly, functional connectivity strength （FCS） and the hub regions were calculated, and the difference was compared between the three groups in FCS. At last, the different brain regions and the abnormal functional connectivity characteristics were determined. Results Different brain regions between HC and MCI- nd （P 〈0. 005） were the left dorsolateral frontal gyrus （FCS enhancement） , right precuneus （ FCS decrease）. Different brain regions between HC and MCI - d （ P 〈 0. 005 ） were right inferior tempo- ral gyrus （FCS decreased） , right dorsolateral frontal gyrus （FCS decreased） , the left middle temporal gyrus （FCS decrease） , right angu- lar gyrus （FCS decrease）. Different brain regions between MCI- nd and MCI -d （P 〈 0. 005 ） were left middle frontal gyrus （FCS de- creased） , right middle frontal gyrus （FCS decreased） , left angular gyrus （FCS decreased） , right angular gyrus （FCS decreased）. The left middle temporal gyrus, right angular gyrus were belonged to the hub regions. Conclusions Emotional network and ＂default - mode＂ network in MCI - d may also be impaired simultaneously. Ddepression may be a potential biomarker of preclinieal AD. It is possible to i- dentify the MCI who is most likely to progress to AD.
出处
《医学研究杂志》
2017年第8期39-44,共6页
Journal of Medical Research
基金
国家自然科学基金资助项目(31371007
81430037
61633018)
北京市自然科学基金资助项目(7161009)
北京市科委首都市民健康培育项目(Z131100006813022
Z161100002616020)
首都医科大学基础临床合作项目(16JL-L08)
中国科学院心理学研究所行为科学重点实验室开放基金资助项目(ZKYKF2016001)
顺义区卫计委基金资助项目(SY2016002)
顺义区张镇政府及张镇卫生院基金资助项目(ZZZZF2016003)
关键词
抑郁
轻度认知障碍
阿尔茨海默病
功能连接强度
脑网络
Depression
Mild cognitive impairment
Alzheimer＇s disease
Functional connectivity strength
Brain network
