摘要
目的:观察分析自拟抑骨质增生汤联合双氯芬酸钠治疗颈腰椎骨质增生的临床疗效并探讨其作用机理。方法:将符合纳入标准的60例颈腰椎骨质增生患者随机分为观察组与对照组,每组30例。对照组患者采用双氯芬酸钠治疗;观察组患者予以自拟抑骨质增生汤联合双氯芬酸钠治疗,两组患者均治疗30天。比较两组患者治疗前后的VAS评分和临床疗效;观察自拟抑骨质增生汤联合双氯芬酸对颈腰椎骨质增生患者血浆中神经递质的影响并探讨其作用机理。结果:治疗前两组患者VAS评分比较,差异无统计学意义(P>0.05),治疗后两组患者VAS评分均明显降低,与治疗前比较差异极显著(P<0.01);治疗后观察组患者VAS评分明显低于对照组,差异显著(P<0.05);观察组患者的总有效率为96.7%,对照组为80.0%,观察组患者治疗效果显著优于对照组,差异有统计学意义(P<0.05)。自拟抑骨质增生汤联合双氯芬酸明显降低颈腰椎骨质增生患者血浆P物质水平,升高强啡肽水平。与治疗前比较,差异具有统计学意义(P<0.01);与对照组治疗后比较,差异具有统计学意义(P<0.05)。结论:自拟抑骨质增生汤联合双氯芬酸钠治疗颈腰椎骨质增生具有较好的临床疗效,其机理可能是通过降低患者血浆P物质水平,升高强啡肽水平而起到治疗颈腰椎骨质增生的作用。
Abstract：Objective：To evaluate the clinical curative effect of self - made anti - hyperostosis decoction in treating cervical and lumbar spine bone hyperplasia, and to discuss the mechanism of its action. Methods：60 patients with cervical and lumbar spine bone hyperplasia were randomly divided into the observation group and the control group, with 30 cases in each group. The control group was treated with diclofenac sodium, corre- spondingly, the observation group was treated with self - made anti - hyperostosis decoction combined with di- clofenac sodium, and the course of the medication was 30 days. The VAS scores and clinical curative effect were compared between the two groups before and after the medication, therefore, the effect of self - made anti -hyperostosis decoction combined with diclofenac sodium was observed and its action mechanism was discussed for treating cervical and lumbar spine bone hyperplasia. Results：Before medication, there was no sta-tistical significance between the two groups in terms of VAS scores （P 〉 0.05 ） ; which were reduced significantly in both groups after medication（ P 〈 0.01 ）, and it was significantly lower in the observation group compared to that in the control group （P 〈 0.05）. The total effective rate of the observation group （96.7%） was superior to that of the control group （ 80.0% ） （ P 〈 0.05 ）. Furthermore, the medication of the observation group reduced the plasma levels of substance P and increased the dynorphin level, of which there were signifi- cant differences between prior medication and post - medication （ P 〈 0. 01 ）, and there were significant differences between the observation group and the control group （ P 〈 0.05 ）. Conclusion ： The self - made anti - hyperostosis decoction combined with diclofenac sodium has good clinical curative effect, and the mech-anism may be associated with reducing the plasma levels of substance P and increasing the dynorphin level in cervical and lumbar spine bone hyperplasia patients.
作者
陆洪军
解云川
李长德
李淑贤
LU Hong - jun XIE Yun - Chuan LI Chang - de LI Shu - xian(The First Affiliated Hospital of Jiamusi University, Jiamusi 154003, China)
出处
《中医药信息》
2017年第4期107-110,共4页
Information on Traditional Chinese Medicine
基金
黑龙江省卫生计生委科研课题(No.2016-290
2016-320)
关键词
颈腰椎骨质增生
自拟抑骨质增生汤
双氯芬酸钠
P物质
Cervical and lumbar spine bone hyperplasia
Self - made anti - hyperostosis decoction
Diclofe- nac sodium
Substance P
