摘要
目的观察杞菊地黄丸治疗不同角膜屈光手术后干眼的临床疗效。方法将不同角膜屈光手术后干眼患者90例(180眼)随机分为两组:治疗组和对照组,对照组局部点0.1%玻璃酸钠滴眼液(海露),治疗组在此基础上加用中成药杞菊地黄丸,空腹口服,10粒/次,3次/日,记录治疗前、后患者自觉症状、角膜荧光素钠染色、泪膜破裂时间、泪液分泌试验等变化情况。结果治疗1个月,治疗组自觉症状较对照组明显改善(P<0.05)。疗效比较,治疗组总有效率为96.7%,对照组为86.7%,两组比较,差异有统计学意义(P=0.006)。FL评分:治疗组治疗前为8.5±2.7,治疗后为1.7±0.6,治疗前后比较差异有统计学意义(P<0.001);对照组治疗前为8.4±3.1,治疗后为3.5±0.9,治疗前后比较差异有统计学意义(P<0.001);两组治疗后比较,t=-15.787,P<0.001,差异有统计学意义,治疗组疗效优于对照组。BUT:治疗组治疗前为(9.20±3.07)s,治疗后为(16.37±3.26)s,治疗前后比较,差异有统计学意义(P=0.005);对照组治疗前为(9.28±3.09)s,治疗后为(12.81±3.03)s,治疗前后比较,差异有统计学意义(P=0.006);两组治疗后比较,t=5.093,P=0.01,差异有统计学意义,治疗组疗效优于对照组。SIT:治疗组治疗前(10.23±3.07)mm,治疗后(19.68±4.37)mm,治疗前后比较,差异有统计学意义(P=0.001);对照组治疗前为(10.26±3.09)mm,治疗后(13.96±4.43)mm,治疗前后比较,差异有统计学意义(P=0.008);两组治疗后比较,t=3.257,P=0.02,差异有统计学意义,治疗组疗效优于对照组。结论治疗不同角膜屈光手术后的干眼,杞菊地黄丸联合0.1%玻璃酸钠滴眼液的疗效优于单纯使用0.1%玻璃酸钠滴眼液。
OBJECTIVE To observe the clinical efficacy of Qiju Dihuang pills on dry eye after corneal refractive surgery.METHODS Ninety cases（180 eyes） with dry eye after corneal refractive surgery were included and randomly divided into treatment group and control group. Patients in control group was treated by 0.1% sodium hyaluronate eye drops; On this basis, subjects in treatment group were administrated with Chinese medicine Qiju Dihuang pills on empty stomach in regime of 10 pill a time, 3 times per day. Data involving symptoms, corneal fluorescein test, tear break-up time, Schirmer I test and other changes were recorded before and after intervention. RESULTS One month after treatment, the symptoms of patients in the treatment group were significantly improved in contrast to control group（P〈0.05）. The total effective rate was 96.7% in the treatment group and 86.7% in the control group, the difference was statistically significant（P=0.006）. FL score： Result of treatment group was 8.5±2.7 before treatment and 1.7±0.6 after treatment, and the difference was statistically significant（P〈0.001）; the score of control group was 8.4±3.1 before treatment and 3.5±0.9 after treatment. The difference was statistically significant（P〈0.001）. The difference of data after treatment between the two groups was statistically significant（t=-15.787, P〈0.001）. In other words, treatment group received more favorable effect than control group. BUT： The level of BUT in the treatment group was 9.20±3.07 s before treatment and 16.37±3.26 s after treatment, and the difference was statistically significant（P=0.005）. The level of BUT in the control group was 9.28±3.09 s before treatment and 12.81 ±3.03 s after treatment, and the difference was statistically significant（P=0.006）. The difference between two groups after treatment was statistically significant（t=5.093, P=0.01）. The BUT efficacy of the treatment group was better than that of the control group. SIT：In treatment group, the average length of SIT was 10.23 ±3.07 mm before treatment and 19.68±4.37 mm after treatment, the difference was statistically significant（P=0.001）; In control group,the average length of SIT was 10.26±3.09 mm before treatment and 13.96±4.43 mm after treatment, the difference was statistically significant（P=0.008）; the difference between the two groups was statistically significant（t=3.257, P=0.02） after treatment. Specifically, the SIT efficacy of the treatment group was better than that of the control group.CONCLUSIONS On dry eye after different corneal refractive surgery, the effect of Qiju Dihuang pills combined with 0.1% sodium hyaluronate eye drops was more effective than 0.1% sodium hyaluronate eye dropsalone.
出处
《中国中医眼科杂志》
2017年第3期150-153,共4页
China Journal of Chinese Ophthalmology
关键词
角膜屈光手术
干眼症
杞菊地黄丸
人工泪液
corneal refractive surgery
dry eye
Qiju Dihuang pills
artificial tears
