摘要
目的 制备更昔洛韦凝胶剂。方法 以卡波普水凝胶为基质制备更昔洛韦凝胶剂 ,采用紫外分光光度法进行含量测定 ,并进行稳定性和皮肤刺激性试验。结果 更昔洛韦在 2 5 2nm处有最大吸收 ,在 4～ 16 μg ml浓度与吸收度线性关系良好。结论 更昔洛韦凝胶剂性质稳定 ,皮肤刺激性小 ,制备简单 ,易于质量控制 ,适用于医院配制。
Objective To prepare ganciclovir gel.Methods The carbomor hydrogel has been chosen as the basic for ganciclovir gel,and the UV method was employed to determine the content. Tests were carried out to investigate the stability and skin irritability. Results Ganciclovir showed a maximum absorbance at 252nm in solution and exhibited a good linear relationship with absorbance over the range of 4～16μg/ml. Conclusion Ganciclovir gel is stable and low in skin irritation with convenient usage as the advantage,easy to control,which means a reliable and proper preparation for the hospital.
出处
《广东药学》
2002年第4期24-25,共2页
Guangdong Pharmaceutical Journal
