摘要
本文对近年来中医药防治他莫昔芬相关性脂肪肝的实验及临床研究进行总结,从病因病机及治疗两部分论述。本病直接病因为感受药毒;病机各家看法不一,分为肝郁气滞、血瘀内阻、气血不足、阴阳亏虚、脾肾不足。治法多采用疏肝理气、活血化瘀、益气养血、平补阴阳、健脾补肾。研究证明中药在抗氧化应激及脂质过氧化、改善胰岛素抵抗、调控线粒体功能、保护肝细胞结构与功能等方面拥有独特优势,具有明显的降脂保肝作用。
This paper summarizes experimental and clinical study of Chinese medicine in prevention and treatment of tamoxifen associated fatty liver in recent years,from the angle of etiology and pathogenesis and therapy. This disease is directly caused by drug toxicity. The pathogenesis have different opinions and divide into liver qi stagnation,blood stasis resistance,deficiency of qi and blood,deficiency of yin and yang,deficiency of spleen-kidney. The treatment should be based on syndrome differentiation,and thecommon treatments are relief liver for smooth qi,blood-activating and statis-dissolving,invigorating qi,nourishing blood,reinforcing yin and yang,strengthening spleen and tonifying kidney. Studies have shown that traditional Chinese medicine has a unique advantage in anti-oxidative stress and anti lipid peroxidation,improving insulin resistance,regulation of mitochondrial function,protecting liver cell structure and function.
出处
《环球中医药》
CAS
2017年第6期772-776,共5页
Global Traditional Chinese Medicine
基金
北京市科委首都市民健康项目培育(Z151100003915128)
关键词
他莫昔芬
脂肪肝
中医治疗
Tamoxifen
Fatty liver
Chinese medicine treatment
