摘要
碳酸酐酶抑制剂 (CAIs)可抑制房水分泌而减少房水的生成 ,从而起到降眼压、治疗青光眼的作用。综述三代 CAIs的构效关系及设计思路 ,介绍具代表性的抗青光眼
Carbonic anhydrase inhibitors (CAIs) can decrease the generation of the aqueous humor by inhibiting the secretion of it, reducing the intraocular pressure for treatment of glaucoma. The structure activity relationship and designing idea of development of the three generations of antiglaucoma CAIs were reviewed. And several representative antiglaucoma CAIs were introduced.
出处
《药学进展》
CAS
2002年第4期202-205,共4页
Progress in Pharmaceutical Sciences
关键词
抗青光眼药物
碳酸酐酶抑制剂
水溶性
脂溶性
结构修饰
Carbonic anhydrase inhibitor
Antiglaucoma
Water solubility
Lipid solubility
Structural modification
