摘要
目的:探讨重组人脑利钠肽(rh-BNP)联合左西孟旦治疗急性心肌梗死合并心力衰竭的临床效果。方法:收集河南省范县人民医院2015年5月~2016年10月80例急性心肌梗死合并心力衰竭患者,随机数字法分为观察者和对照组各40例,两组患者均给予基础治疗,对照组给予左西孟旦治疗,在此基础上观察组给予重组人脑利钠肽(rh-BNP)治疗,比较两组患者的临床治疗效果。结果:治疗后联合组左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、脑钠肽(BNP)水平低于对照组,差异有统计学意义(P<0.05);左室射血分数(LVEF)、心输出量(CO)高于对照组,差异有统计学意义(P<0.05);联合组收缩压(SBP)、心率(HR)、呼吸频率(RR)低于对照组,动脉血氧饱和度(SaO_2)高于对照组,差异有统计学意义(P<0.05)。结论:采用重组人脑利钠肽(rh-BNP)联合左西孟旦可有效改善急性心肌梗死合并心力衰竭患者心功能情况,缓解临床症状,值得临床推广应用。
Objective：To investigate the clinical effect of recombinant human brain natriuretic peptide（rh-BNP）combined with levosimendan in the treatment of acute myocardial infarction complicated with heart failure.Methods：80 patients with acute myocardial infarction complicated with heart failure treated in Fan County People’s Hospital,Henan Province were randomly divided into observation group and control group with 40 in each group.All the patients were given basic treatment,the control group was given levosimendan treatment,on the basis of which the observation group were given recombinant human brain natriuretic peptide（rh-BNP）treatment,and then compare treatment efect of the two groups.Results：After treatment,the left ventricular systolic diameter（LVESD）,left ventricular end diastolic diameter（LVEDD）and brain natriuretic peptide（BNP）of the combination group were significantly lower than those in the control group（P〈0.05）.Left ventricular ejection fraction（LVEF）,cardiac output（CO）of the combination group were higher than those of the control group（P〈0.05）.Systolic blood pressure（SBP）,heart rate（HR）and respiratory rate（RR）of the combination group were lower than those of the control group（P〈0.05）.Arterial oxygen saturation（SaO2）was higher than that of the control group,and the difference was statistically significant（P〈0.05）.Conclusion：Recombinant human brain natriuretic peptide（rh-BNP）combined with levosimendan can effectively improve the cardiac function of patients with acute myocardial infarction and heart failure,relieve clinical symptoms and deserve clinical application.
出处
《数理医药学杂志》
2017年第7期1037-1038,共2页
Journal of Mathematical Medicine
关键词
重组人脑利钠肽
左西孟旦
急性心肌梗死
心力衰竭
recombinant human brain natriuretic peptide
levosimendan
acute myocardial infarction
heart failure
