摘要
目的筛选珠卡赛辛乳膏制备工艺,并与Zuacta乳膏进行对比。方法以耐寒稳定性、耐热稳定性、离心稳定性、外观作为指标,对处方配比进行筛选,通过正交实验对工艺条件进行优化。采用改良Franz扩散池法,考察自制品与Zuacta乳膏的体外透皮吸收情况。结果优化后的工艺条件为,乳化温度70℃、搅拌速度2 000 r·min^(-1),乳化时间30 min,主药加入油相中。自制品与Zuacta乳膏外观、透过速率以及累积透过率差异无统计学意义。结论所制备的珠卡赛辛乳膏处方配方合理,质量稳定,体外透皮效果好,与Zuacta乳膏基本一致。
Objective To select the optimal preparation technology of zucapsaicin cream and compare it with zuacta cream. Methods Cold stability,ther^nal stability,centrifugal stability,and appearance were used as indicators to select the ratio of prescription. In this study preparation technology ＂was optimize by using orthogonal experiment method, and transdermal absorption of the homemade zucapsaicin cream and zucata cream were investigated by employing modified Franz diffusion pool. Results The optimized preparation technology was as follows,emulsifying temperature was maintained at 70 ℃ , the stirring speed was set at 2 000 r · min^-1 ,the main medicine was added into the oil phase,emulsifying time was 30 min.The results showed that there was no significant difference between the homemade zucapsaicin cream and the reference Zuacta cream. Conclusion The homemade zucapsaicin were tested to have reasonable ratio of prescription, stability, and definite transdermal effect, which was basically in accordance with zuacta cream.
出处
《医药导报》
CAS
2017年第7期774-777,共4页
Herald of Medicine
基金
湖北省高端人才计划资助项目(RBZY13001)
