摘要
原发性干燥综合征(primary Sj9gren syndrome,p SS)是一类多系统受累的自身免疫病,与恶性肿瘤之间存在千丝万缕的联系。研究提示p SS与淋巴瘤的发生明确相关。黏膜相关淋巴样组织淋巴瘤是p SS患者中最常见淋巴瘤类型;而腮腺肿大、皮肤血管炎、CD4+T细胞减少、补体降低、类风湿因子阳性等对淋巴瘤的发生有提示意义。实体肿瘤中甲状腺癌在干燥综合征患者中发病率高于普通人群,而结肠癌发病率较低。本文就p SS并发恶性肿瘤的流行病学特点、临床特征、预测指标和预后的研究进展进行综述。
Primary Sjtigren＇s syndrome （pSS） is a chronic autoimmune disorder with multiple system involvements, which inextricably associated with malignant diseases. A series of studies have shown that patients with pSS have a higher incidence of lymphoma than the general population. Mucosa-associated lymphoid tissue lymphoma constitutes the majority of Non-Hodgkin Lymphoma subtypes. Parotid gland en- largement, skin vasculitis, CD4^＋T cell lymphopenia, hypocomplementemia, and a high level of rheuma- toid factor are predictors for lymphoma development. As for solid tumors, thyroid cancer has a higher risk in pSS than the general population, while colon cancer has a lower risk in pSS. In this review, we summa- rize the epidemiological characteristics, clinical features, predictive factors, and outcomes in pSS associ- ated with malignancies.
出处
《中华临床免疫和变态反应杂志》
2017年第2期174-178,共5页
Chinese Journal of Allergy & Clinical Immunology
