摘要
目的研究SiewertⅡ型食管胃交界腺癌患者围手术期血清白介素(IL)-6浓度变化,评估微创手术和开放手术对患者手术创伤的程度。方法选取接受Sweet食管切除术的SiewertⅡ型食管胃交界腺癌切除术患者60例。其中30例接受微创Sweet食管切除术,30例接受传统左进胸开放Sweet食管切除术。用ELISA法检测IL-6值,t检验和χ2检验比较两组患者术前1天、术后第1、3、7天血清IL-6浓度变化情况。结果两组患者在性别、年龄和术前合并症方面差异无统计学意义。两组患者在术后病理分期、手术时间、术中出血量、术后死亡率和总并发症发生率方面差异无统计学意义。两组患者术前1天和术后第7天血清IL-6浓度差异无统计学意义。两组术后第1天、第3天血中IL-6值的差异有统计学意义(P<0.05)。两因素重复测量资料的方差分析提示:两组术后不同时间点血清IL-6浓度的差异有统计学意义(P<0.05)。结论接受微创Sweet食管切除术的SiewertⅡ型食管胃交界腺癌患者术后创伤低于传统开放手术。
Objective To evaluate the degree of trauma from minimally invasive surgery and open surgery of Siewert type II esophageal gastric junction adenocarcinoma by investigating the variation of IL-6 concentration. Methods60 patients with Siewert type Ⅱ esophageal gastric junction adenocarcinoma were selected and received minimally invasive surgery and open surgery in our center.Of those 60 patients,30 underwent minimally invasive surgery and30 recieved open surgery. The concentration of IL-6 were detected by ELISA. t test and χ2test were used to compare the changes of serum IL-6 concentration between the two groups before operation and on the 1st day,the 3th day and the 7th day after surgery.Results The two groups were similar in terms of age,sex and preoperative complications. The minimally invasive surgery approach was associated with no significant decrease in postoperative pathological stage,surgical blood loss,duration of operation,peirioperative mortality and the overall incidence of complications relative to the open surgery approach. There was no significant difference between two groups in the day before surgery,the 7th day after surgery of the concentration of IL-6 of two groups. The minimally surgery approach was associated with significantly lower concentration of IL-6 of the first day and the 3th day after surgery than the open surgery approach（ P〈0. 05）. There were statistically significant difference in the concentration of IL-6 of different time points of two groups according to bivariate repeated measurement data（ P 〈0. 05）. Conclusion The patients with Siewert type II esophageal gastric junction adenocarcinoma have lower operative wound than open surgery.
出处
《安徽医科大学学报》
CAS
北大核心
2017年第7期1017-1020,共4页
Acta Universitatis Medicinalis Anhui
基金
安徽省科技攻关计划项目(编号:1501041143)
