摘要
蛋白质组学迅猛发展,越来越多与肿瘤发生发展相关的蛋白质被发现,并被应用于临床诊断。Argonaute2蛋白通过参与构成RNA诱导的沉默复合体,其自身催化及自身过表达功能,在人类肿瘤的发生发展中扮演了重要角色,逐渐成为研究焦点。就Argonaute2蛋白结构、功能及在肿瘤中的作用机制方面的研究新进展做一综述。
With the rapid development of proteomics,proteins related to tumorigenesis and progression have been continuously discovered and applied to clinical diagnosis. By constituting RNA-induced silencing complex（ RISC）,selfcatalysis and overexpression,Argonaute2 plays an important role in human tumorigenesis and progression,and is becoming a research focus. In this article,we will reviewthe research advances on the structure,function and mechanism of Argonaute2 in tumor development.
作者
张彦惠
董频
ZHANG Yanhui DONG Pin.(Department of Otolaryngology Head and Neck Surgery, Shanghai General Hospital, Shanghai 200080, Chin)
出处
《山东大学耳鼻喉眼学报》
CAS
2017年第3期95-99,共5页
Journal of Otolaryngology and Ophthalmology of Shandong University
