摘要
目的观察血清表面活性蛋白D(surfactant protein D,SP-D)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性加重期及缓解期的水平变化及其与ADO指数的相关性,研究血清SP-D水平对于COPD患者预后的指导意义。方法收集33名COPD急性加重期患者年龄、性别、身高、体质量等基本资料,进行肺功能检查及改良版英国医学研究会呼吸问卷(modified version of the British medical research council respiratory questionnaire,mMRC),分别于入院第2天及经治疗急性加重症状缓解后取血用酶联免疫吸附法(ELISA)测定SP-D水平,并将血清SP-D水平与年龄等进行相关性分析。结果经过治疗后,缓解期COPD患者血清SP-D水平较急性加重期有显著下降(P<0.05);急性加重期血清SP-D水平与ADO指数无相关性,缓解期血清SP-D水平与ADO指数具有负相关性。结论血清SP-D水平可以反映COPD疾病的活动性,可以作为检测COPD是否处于急性加重期的标记物;COPD稳定期患者的血清SP-D水平可以作为评估预后的指标。
Objective To explore the guiding significance of serum SP-D in chronic obstructive pulmonary disease （COPD） patients by investigating the changes of serum surfactant protein D（SP-D） level during exacerbation stage and remission stage of COPD and its re- lationship with ADO index. Methods Basic information and peripheral blood samples were collected from 33 COPD patients in exac- erbation stage and remission stage. Pulmonary functions and modified version of the British medical research council respiratory ques- tionnaire were performed for all patients. Results The serum SP-D levels were significantly different between COPD patients in exac- erbation stage and remission stage（P 〈 0.05 ）. Serum SP-D level was negatively correlated with ADO index in remission stage, but not in exacerbation stage. Conclusion Serum SP-D level increases early in the acute exacerbation stage of COPD,which could be a po- tential diagnostic biomarker for COPD exacerbation. Serum SP-D level could predict the prognosis for COPD patients in stable stage.
作者
邵红霞
李莉
吴琦
华静娜
侯志丽
SHAO Hongxia LI Li WU Qi HUAJlngna HOU Zhili(Department of Respiratory, Tianjin Haihe Hospital, Tianjin 300350, China Tianjin Institute of Respiratory Diseases Tuberculous Department of Tianjin Haihe Hospital)
出处
《山西医科大学学报》
CAS
2017年第6期575-577,共3页
Journal of Shanxi Medical University
基金
天津市卫生局科技基金资助项目(2014KY17)
