摘要
目的观察气管插管拔管后使用布地奈德雾化吸入对于预防喉部水肿的临床疗效。方法选取急诊监护室于2015年1月至2016年12月期间行气管插管并顺利拔管的危重患者,以随机数字法将其均分为实验组和对照组。实验组拔管后给以布地奈德雾化吸入,对照组予以生理盐水雾化吸入。观察两组患者呼吸困难的发生率、血氧饱和度(SpO_2)、动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)、呼吸频率(RR)的差异性。结果与对照组相比,雾化结束后30 min时实验组PaO_2显著升高、SpO_2显著升高,差异均有统计学意义(P<0.05),而PaCO_2及RR则无明显变化;雾化结束后60 min时实验组PaCO_2显著下降、SpO_2显著升高、RR显著回落,差异均有统计学意义(P<0.05),而PaO_2则无明显变化;实验组患者在观测期内发生拔管后喉部水肿的比率显著降低(P<0.05)。结论使用布地奈德雾化治疗气管插管拔管后可有效改善氧合、降低喉部水肿发生几率,值得临床推广。
Objective To observe the prevention effect on laryngeal edema after tracheal extubation with budesonide nebulization inhalation. Methods The research chose patients taken tracheal intubation and tracheal extubation from Jan. 2015 to Dec. 2016 in emergency care unit of the Central Hospital of Wuhan,and randomly divided the patients into experimental group and control group. The experimental group was treated with budesonide nebulization inhalation after tracheal extubation while the control group was treated with normal saline nebulization inhalation,the indexes of dyspnea incidence,blood oxygen saturation(SpO_2),arterial partial pressure of oxygen(PaO_2),arterial partial pressure of carbon dioxide(PaCO_2)and respiratory rate(RR)were observed. Results 30 min after nebulization inhalation,compared with the control group,the indexes of experimental group of PaO_2 and SpO_2 increased,the differences were statistic significant( P < 0. 05),the indexes of PaCO_2 and RR had no obvious change. 60 min after nebulization inhalation, in the experimental group, the PaCO_2 significantly decreased, the SpO_2 significantly increased, the RR significantly fell down, the differences were statistic significant( P < 0. 05);the PaO_2 had no obvious change. The incidence of laryngeal edema in experimental group was obvious lower than that in control group( P < 0. 05).Conclusion Budesonide nebulization inhalation after tracheal extubation can effectively improve oxygenation and reduce laryngeal edema,it is worthy to popularize.
出处
《江汉大学学报（自然科学版）》
2017年第3期251-254,共4页
Journal of Jianghan University：Natural Science Edition
关键词
喉部水肿
布地奈德
雾化吸入
甲基泼尼松龙
laryngeal edema
budesonide
nebulization inhalation
methylprednisolone
