摘要
目的:探讨丹红注射液联合尼莫地平治疗血管性痴呆的临床疗效及其对患者血清血管内皮生长因子(VEGF)、雌二醇(E2)、抗凋亡因子(Livin)、β淀粉样蛋白(β-Ap)的影响。方法:入选我院2014年5月~2016年5月间收治的血管性痴呆患者112例,随机分成对照组(n=56)和治疗组(n=56)。2组患者除给予常规治疗以外,对照组仅给予尼莫地平治疗,观察组给予丹红注射液联合尼莫地平治疗,2组均以12 w为一个疗程。观察并记录治疗前后2组患者的简易精神状态量表(MMSE)及日常生活活动能力量表(ADL)评分,对比其临床疗效,并对比治疗前后2组患者血清VEGF、E2、Livin及β-Ap水平,同时记录2组治疗期间的不良反应。结果:治疗后2组患者的MMSE、ADL评分均显著改善,且观察组明显优于对照组,差异显著(P<0.05);观察组总有效率(89.3%)明显高于对照组(73.2%),差异显著(P<0.05);治疗后2组患者的血清检测指标均显著改善,且观察组明显优于对照组,差异显著(P<0.05);在治疗期间2组患者均未发生不良反应。结论:丹红注射液联合尼莫地平在血管性痴呆治疗中疗效显著、安全性高,其作用机制与改善患者的血清VEGF、E2、Livin、β-Ap水平有关。
Objective： To investigate on serum vascular endothelial growth factor in patients with vascular dementia clinical curative effect of Danhong injection therapy combined with nimodipine （VEGF）, estradiol （E2）, anti apoptotic factor （Livin）, amyloid beta （beta -Ap） level of influence. Methods： 112 cases of vascular dementia were randomly divided into control group （n = 56） and treatment group （n =56） from May 2014 to May 2016 in our hospital. Two groups of patients were given conventional treatment, and the control group plus nimodipine treatment, observation group plus Dan Hong injection combined with nimodipine treatment. The two groups were 12 weeks for a course of treatment. Observed and recorded Mini Mental State Scale （MMSE） and activities of daily living scale （ADL） score before and after treatment. Compare the clinical curative effect and VEGF, E2, Livin and β-Ap in serum before and after treatment, and record the occurrence of adverse reactions between the two groups treatment. Results： after treatment, two groups of pa- tients with MMSE and ADL scores were significantly improved, and the observation group was significantly better than the control group, the difference was significant （P 〈0. 05） ; the total efficiency of observation group （89. 3% ） was significantly higher than the control group （73. 2% ）, significant difference （P 〈0. 05 ） ; after treatment, serum indexes of two groups were significantly improved, and the observation group was significantly better than the control group, the difference was significant （ P 〈 0. 05 ） ; and in the two groups dur- ing treatment had no adverse reactions. Conclusion ： Dan Hong injection combined with nimodipine in the treatment of vascular dementia curative effect is remarkable, high safety, and its mechanism is relative to improve the level of serum VEGF, E2, -Ap, Livin.
出处
《成都中医药大学学报》
2017年第2期53-55,共3页
Journal of Chengdu University of Traditional Chinese Medicine
基金
湖北省自然科学基金面上项目(2013CFC053)
