摘要
NK/T细胞淋巴瘤(NK/T-cell lymphoma,NKTCL)的发病与EB病毒(epstein-barr virus,EBV)感染、基因异常、染色体异常、信号通路及蛋白表达异常相关。本文就NKTCL相关基因异常的研究进展做一简要综述。NKTCL基因异常包括基因突变和缺失等,可影响细胞增殖、分化、凋亡及信号转导。其中,EBV相关基因LMP1表达产物为LMP1蛋白(latent membrane protein 1),破坏细胞信号传导通路;KIR2DL4、EZH2、DDX3X及c-Myc基因异常通过调节免疫应答、DNA转录等途径影响细胞周期;TP53、JAK3、PTPRK、PRDM1及BCOR基因异常通过编码蛋白、影响细胞内信号转导通路等途径抑制细胞凋亡,进而导致细胞的恶性转化。在基因水平对NKTCL进行深入研究会帮助我们进一步认识NKTCL的发病机制,为疾病的治疗提供新的思路与靶点,完善预后评价体系。
The incidence of NK/T- cell lymphoma（NKTCL） is associated with Epstein -Barr virus（EBV） infec- tion, genetic abnormalities, chromosomal abnormalities, signaling pathways and abnormal protein expression abnormali- ties. In this paper,we briefly reviewed the advances in NKTCL -related gene abnormalities. NKTCL gene abnormali- ties, including gene mutations and deletions, can affect cell proliferation, differentiation, apoptosis and signal transduc- tion. The prodwtion of gene expression of EBV - related - gene LMP1 is LMP1 （ latent membrane protein 1 ）, which damages the cell signaling pathway. The abnormality of gene KIR2.DIA, EZH2, DDX3X and c - Myc affects the cell cycle through regulating the immune response and DNA transcription. While the abnormality of gene TP53, JAK3, FI＇- PRK,PRDM1 and BCOR inhibits apoptosis through encoding proteins and affecting intracellular signal transduction pathway, therefore induces cell malignant transformation. Further study of NKTCL at the gene level will help us to fur- ther understand the pathogenesis of NKTCL, provide new ideas and targets for the treatment of disease and improve the prognostic evaluation system.
出处
《现代肿瘤医学》
CAS
2017年第13期2174-2178,共5页
Journal of Modern Oncology
