摘要
目的总结外泌体对缺血再灌注器官损伤的保护作用,为其治疗提供新思路。方法广泛查阅近年国内外与外泌体治疗缺血再灌注损伤相关的文献,分析总结其作用机制。结果外泌体体积小,存在于血液、脑脊液、尿液等细胞外液中,能够穿透血脑屏障,可通过多种分子机制对心脏、脑等器官的缺血再灌注损伤起到保护作用,并且无肝、肾副作用。结论外泌体治疗可能成为逆转缺血再灌注器官损伤的新方法,了解外泌体对缺血再灌注损伤的保护作用及可能机制具有重要意义。
Objective To investigate the protective effect of the exosome on the organ damage induced by ische- mia-reperfusion （l/R） so as to provide a new way for the treatment of I/R damage. Methods The literature related to the treatment of I/R damage was reviewed and analyzed. Results The exosome volume is small and it is present in blood, cerebrospinal fluid, and urine, which has the function to cross the blood-brain barrier, and protect the heart, brain and other organs after I/R damage. Conclusion Exosome is a new material for the treatment of I/R organ injury, and it is important to understand the protective effect and possible mechanism.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2017年第6期751-754,共4页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家自然科学基金资助项目(81330016
81630038
81270724)
国家重点基础研究发展计划项目(973计划)(2013CB967404
2012BAI04B04)
四川省科技计划项目(2014SZ0149
2016TD0002)~~
关键词
外泌体
缺血再灌注
器官损伤
治疗
Exosome
ischemia-reperfusion
organ injury
treatment
