摘要
目的:观察圣愈汤早期应用对缺血性脑卒中患者吞咽功能以及语言功能的改善作用。方法:选取我院康复科2014年4月~2016年3月收治的缺血性脑卒中患者92例,按随机数字表法分组,分别46例,对照组予以促脑代谢、清除自由基治疗;研究组在促脑代谢、清除自由基上予以圣愈汤加减治疗,共治疗14天为1疗程,采血测定炎症介质、神经相关以及氧化应激指标,评定饮水试验评级、NIHSS评分、失语症简易量表以及MMSE评分,同时对比临床疗效及不良反应状况。结果:与治疗前比较,两组治疗后饮水试验评级、NIHSS评分降低,失语症简易量表、MMSE评分升高,血清IL-6、TNF-α、CRP水平降低,BDNF、NSE、S100β水平降低,NO、MDA水平降低,CAT、SOD水平升高(P<0.05);与对照组比较,研究组治疗后饮水试验评级、NIHSS评分较低,失语症简易量表、MMSE评分较高,血清IL-6、TNF-α、CRP水平较低,BDNF、NSE、S100β水平较低,NO、MDA水平较低,CAT、SOD水平较高(P<0.05);对照组有效率73.91%与研究组有效率91.30%数据对比,研究组高于对照组(P<0.05)。结论:圣愈汤早期应用对缺血性脑卒中患者吞咽功能、语言功能具有改善作用,与改善炎症介质、神经相关以及氧化应激指标关系密切。
Objective ： To study the effect of Shengyu Decoction on swallowing function and language function in patients with ischemic stroke. Methods： Forty-two patients with ischemic stroke admitted to our department from April 2014 to March 2016 were divided into groups according to the method of random number table, and the controlled group was treated with free radical treatment. The study group were treated more with Shengyu Decoction for 14 days. Blood samples were collected to measure in- flammatory mediators, neurological and oxidative stress. Blood test scores, NIHSS score, aphasia simple scale And MMSE score, and the clinical efficacy and adverse reaction status were compared. Results： Compared with before treatment, the scores of drinking water test, NIHSS, aphasia simple scale, MMSE score in 2 groups increased, levels of serum IL-6, TNF-α and CRP de- creased, levels of BDNF, NSE and S100β decreased, levels of NO and MDA decreased, levels of CAT and SOD increased （P 〈 0.05 ）, compared with the controlled group, the scores of drinking water test, NIHSS, aphasia simple scale, MMSE score in the study group were higher, levels of serum IL-6, TNF-α and CRP were lower, levels of BDNF, NSE and S100β were lower, levels of NO and MDA were lower, levels of CAT and SOD were higher （ P 〈 0.05 ） , the effective rate in the controlled group （73. 91% ） was lower than the study group （91. 30% ）, （P 〈 0.05）. Conclusion： Shengyu Decoction can improve the swallowing function and language function of patients with ischemic stroke, and it is closely related to the improvement of inflammatory medi- ators, nerve related and oxidative stress.
出处
《四川中医》
2017年第5期136-140,共5页
Journal of Sichuan of Traditional Chinese Medicine
关键词
圣愈汤
缺血性脑卒中
吞咽功能
语言功能
Shengyu Decoction
Ischemic stroke
Swallowing function
Language function
