摘要
目的探讨超声波联合普罗布考片对脑梗死患者颈动脉粥样硬化(CAS)斑块的治疗效果。方法收集发病72h以内的急性脑梗死并伴有CAS斑块形成的患者共126例,其中对照组、观察组各63例。所有患者给予普罗布考片调脂及其他常规治疗。观察组另给予颈动脉斑块对应体表部位超声波治疗,3个疗程后结束超声波治疗,仍保留普罗布考片等常规治疗直至第6个月末结束观察。治疗前、后分别行颈动脉彩超和经颅多普勒检查(TCD)测定血流动力学参数。结果治疗后,观察组的颈总动脉内-中膜厚度[(1.73±0.59)mm]、Crouse积分(4.21±0.63)水平均显著低于对照组[(1.84±0.67)mm,(4.37±0.59)],差异有统计学意义(P<0.05);颈总动脉舒张末期流速(EDV)水平显著上升,阻力指数(RI)明显下降;TCD结果显示,观察组大脑中动脉的平均血流速度较对照组显著升高,而RI水平显著下降,差异有统计学意义(P<0.05)。结论超声波联合普罗布考片治疗对脑梗死患者的CAS斑块具有显著治疗作用,并且对颈动脉血流及大脑血供存在改善作用。
Objective To explore the effects of combined therapy of ultrasound and probucol on carotid atherosclerotic plaque （CAS） in patients with cerebral infarction.Methods A total of 126 patients with acute cerebral infarction with CAS plaque were recruited,including 63 cases in both control group and observed group.All patients were given probucol and other common treatment,while the observed patients were additionally given the ultrasound therapy for 3 courses.After the finish of the ultrasound treatment,the probucol and common treatment remained until the end of the 6th month.The carotid artery ultrasound examination and transcranial doppler （TCD） were done before and after the study.Results After treatment,the intima-media thickness （IMT） [（1.73±0.59）mm]and Crouse integration （4.21±0.63） of observed group were significantly lower than that of the control group[（1.84±0.67）mm,（4.37±0.59）],the end diastolic velocity （EDV） of the carotid artery and resistance index （RI） of observed patients were significantly higher and lower than controls （P〈0.05）.TCD showed the mean velocities （Vm） were significantly higher than the control group and RI of middle cerebral artery in observed group were significantly lower than that of the control group （P〈0.05）.Conclusion The combined therapy of ultrasound and probucol is effective in treating the carotid atherosclerotic plaque,which could also improve the carotid arterial and cerebral blood flow.
出处
《检验医学与临床》
CAS
2017年第10期1372-1373,1376,共3页
Laboratory Medicine and Clinic
基金
河北省秦皇岛市科技支撑计划资助项目(201602A201)
关键词
颈动脉粥样硬化
超声波治疗
脑梗死
血流动力学
carotid atherosclerosis
ultrasound therapy
cerebral infarction
hemodynamics
