摘要
目的探讨癌胚抗原(CEA)联合神经源特异性烯醇化酶(NSE)对小细胞肺癌的诊断效能。方法选择100例小细胞肺癌患者作为研究组,100例肺部良性疾病患者作为对照组。采集患者静脉血,采用化学发光法检测血清CEA水平,采用电化学发光法检测血清NSE水平。计算CEA、NSE及CEA联合NSE诊断小细胞肺癌的敏感度、特异度。结果 CEA诊断小细胞肺癌的敏感度和特异度分别为77.8%和80.2%;NSE诊断小细胞肺癌的敏感度和特异度分别为73.2%和79.7%;CEA联合NSE诊断小细胞肺癌的敏感度和特异度分别为89.2%和95.4%,均高于CEA或NSE单独诊断结果。结论 CEA联合NSE对小细胞肺癌具有较高的诊断价值,可明显提高诊断敏感度和特异度,对小细胞肺癌的早期发现和治疗具有重要意义。
Objective To evaluate the diagnostic value of carcinoembryonic antigen in combination with neurogenic specific enolase （NSE） in the diagnosis of small cell hmg cancer. Method In this retrospective study, 100 small cell lung cancer patients and 100 cases with benign lung diseases were included, from which the venous blood were collected to de- tect serum CEA by chemiluminesence, and serum NSE by electrochemiluminescence. The sensitivity and specificity of CEA, NSE and CEA ＋ NSE in diagnosing small cell lung cancer were compared. Result The sensitivity and specificity of CEA in the diagnosis of small cell lung cancer were 77.8% and 80.2%, compared with 73.2% and 79.7% of NSE. And it were 89.2% and 95.4% for CEA ＋ NSE, which were significantly higher than CEA or NSE alone. Conclusion CEA combined with NSE is highly effective in the diagnosis of small cell lung cancer, with significantly improved sensitivity and specificity, and is fundamental for the early detection and treatment planning of lung cancer.
出处
《癌症进展》
2017年第3期280-282,共3页
Oncology Progress
