摘要
泛素是一种普遍存在于真核细胞中的小分子量蛋白质.E1-E2-E3三步级联反应形成的泛素化修饰,是细胞中最常见、多样化和多功能的蛋白质翻译后修饰,参与蛋白质水解、信号传导等各种生命活动.本文综述了近3年来泛素领域的研究进展,并着重于论述泛素化系统在肿瘤、DNA损伤应答以及神经退行性疾病中的作用.
Ubiquitin, a highly conserved 76-amino-acid polypeptide widely present in eukaryotic cells, is covalently attached to substrate proteins through the E1-E2-E3 cascade. Ubiquitination is involved in a myriad of cellular functions, including protein degradation, signal transduction, DNA damage and repair, transcription regulation, cell cycle progression, and tumorigenesis. In this review, we discuss the basic concept of protein ubiquitination, and focus on its roles in the initiation and progression of cancers, DNA damage response, and neurodegenerative disorders such as Alzheimer＇s disease, Parkinson＇s disease, and Huntington＇s disease. These knowledge is staring to be exploited to develop both drugs and therapy strategies against these diseases.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2017年第5期377-384,共8页
Progress In Biochemistry and Biophysics
基金
985高校专项基金资助项目(WF114117001/004
WF220417001)~~
关键词
泛素化
肿瘤
DNA损伤应答
神经退行性疾病
ubiquitination, cancer, DNA damage response, neurodegenerative diseases
